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  • 27-June-2018

    English

    Test No. 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage

    This Test Guideline describes an in vitro procedure allowing the identification of chemicals (substances and mixtures) not requiring classification and labelling for eye irritation or serious eye damage in accordance with UN GHS. It makes use of reconstructed human cornea-like epithelium (RhCE) which closely mimics the histological, morphological, biochemical and physiological properties of the human corneal epithelium. The test evaluates the ability of a test chemical to induce cytotoxicity in a RhCE tissue construct, as measured by the MTT assay. Coloured chemicals can also be tested by used of an HPLC procedure. RhCE tissue viability following exposure to a test chemical is measured by enzymatic conversion of the vital dye MTT by the viable cells of the tissue into a blue MTT formazan salt that is quantitatively measured after extraction from tissues. The viability of the RhCE tissue is determined in comparison to tissues treated with the negative control substance (% viability), and is then used to predict the eye hazard potential of the test chemical. Chemicals not requiring classification and labelling according to UN GHS are identified as those that do not decrease tissue viability below a defined threshold (i.e., tissue viability > 60%, for UN GHS No Category).
  • 23-June-2018

    English

    Safety Assessment of Transgenic Organisms in the Environment, Volume 8 - OECD Consensus Document of the Biology of Mosquito Aedes aegypti

    Volume 8 of the Series contains the first biosafety ‘consensus document’ to deal with the biology of an insect, the mosquito Aedes aegypti. Issued by the OECD Working Group on the Harmonisation of Regulatory Oversight in Biotechnology, the science-based consensus documents collate information for use during the regulatory risk assessment of biotechnology products, i.e. transgenic organisms (plants, animals, micro-organisms) when intended for release in the environment. Ae. aegypti mosquito is vectoring yellow fever, dengue, Zika and Chikungunya diseases in tropical and sub-tropical regions worldwide. Biotechnological applications are developed to control the mosquito population and reduce virus transmission. The book provides information on Ae. aegypti taxonomy, morphology, life cycle, reproductive biology, genetics, ecology, interactions with other species and the environment. The mosquito effects on human and animal health, and the control strategies/specific programmes to limit its development are also summarised.
  • 6-June-2018

    English

    Economic valuation in 1-Methyl-2-pyrrolidone (NMP) regulation - Environment Working Paper

    This paper gives an overview of economic assessments of the benefits of the control of 1-Methyl-2-pyrrolidone, an organic solvent, used in a number of sectors. Health risks associated with the manufacture of NMP include the risk of stillbirth and developmental retardation to pregnant workers, as well as a variety of chronic and acute effects, including respiratory effects.

  • 6-June-2018

    English

    Economic assessments of the benefits of regulating mercury - Environment Working Paper

    This paper gives an overview of economic assessments of the benefits of the control of emissions of mercury compounds, their completeness from a social cost point of view and the magnitudes of the values attached to mercury compounds in different contexts. The assessments have been conducted in the context of coal-fired electricity generation and the valuation of human health impacts linked to ingestion of methylmercury.

  • 6-June-2018

    English

    Socio-economic assessment of phthalates - Environment Working Paper

    This paper gives an overview of economic assessments of the benefits of the control of exposure to phthalates, a group of chemicals with numerous uses, most importantly, as a plasticiser to make rigid plastics like PVC flexible. There is significant concern that these substances can act as endocrine disrupting chemicals (EDCs), affecting both human health and ecosystems.

  • 6-June-2018

    English

    Economic Valuation in Formaldehyde regulation - Environment Working Paper

    This paper gives an overview of economic assessments of the benefits of the control of formaldehyde and reflects on developments in its risk management and regulation. Formaldehyde is used in the manufacture of resins, as a disinfectant and fixative and as a preservative in consumer products. Formaldehyde exposure can be harmful to human health.

  • 27-May-2018

    English

    Council Act: Revision to the "Decision-Recommendation on the Co-operative Investigation and Risk Reduction of Chemicals"

    The Decision-Recommendation on the Co-operative Investigation and Risk Reduction of Chemicals revises and replaces a 1991 Decision-Recommendation of the Council. The Decision-Recommendation is composed of two parts: Part A focuses on the development of harmonised hazard and exposure assessment methodologies for chemicals and Part B focuses on risk prevention and reduction.

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  • 4-May-2018

    English

    Memorandum of Understanding between the OECD and the Guangdong Provincial Centre for Disease Control and Prevention

    The OECD welcomed a Memorandum of Understanding (MOU) between the Guangdong Provincial Centre for Disease Control and Prevention and the OECD which will support China’s efforts in chemicals regulation and policy making.

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  • 22-March-2018

    English

    Economic assessment and valuations of environmental and health impacts caused by Perfluorooctanoic acid (PFOA) and its salts - Environment Working Paper

    Perfluorooctanoic acid (PFOA) is being used in fluoropolymer production, as surface treatment agents and for the manufacture of side-chain fluorinated polymers. However, there is evidence that PFOA and its salts have a number of hazardous properties that may cause harm to human health and the environment. This report evaluates existing economic assessments and valuations of impacts arising from PFOA and its salts.

  • 3-January-2018

    English

    Exposure Assessment

    Risks to human health and the environment posed by chemicals is determined by the chemical-specific hazard properties and the extent of exposure to chemicals. Read more on the OECD work in developing and harmonising methods for assessing the exposure of chemicals to humans and the environment.

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