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  • 2-March-2021

    English, PDF, 2,727kb

    Guidance on Key Considerations for the Identification and Selection of Safer Chemical Alternatives

    As the demand for safer chemicals grows, the field of alternatives assessment is becoming increasingly important in guiding the transition towards safer, less toxic alternatives. A major limitation that can hinder efforts is the lack of consistent criteria for defining “safer" alternatives. This guidance outlines key considerations for the identification and selection of safer alternatives.

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  • 2-March-2021

    English

    Substitution of hazardous chemicals

    As the demand for safer chemicals grows, the field of alternatives assessment is becoming increasingly important in guiding the transition towards safer, less toxic alternatives. A major limitation that can hinder efforts is the lack of consistent criteria for defining “safer" alternatives. This guidance outlines key considerations for the identification and selection of safer alternatives.

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  • 19-February-2021

    English

    Emission Scenario Documents

    This OECD Emission Scenario Document (ESD) is intended to provide information on the sources, use patterns, and potential release and exposure pathways of non-volatile chemicals used in Aqueous Film-Forming Foams (AFFFs) in firefighting applications. It presents standard approaches for estimating the environmental releases. of and occupational exposures to chemicals used in AFFF.

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  • 18-February-2021

    English

    Biocides

    The objective of the OECD Biocide Programme is to attain a harmonised approach in the regulation of biocides in all OECD countries. The OECD is thus working on harmonising the main data requirements for biocides and the methodologies for the interpretation of these data.

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  • 17-February-2021

    English, PDF, 1,537kb

    Draft TG Metal Release 15Feb 2021 EC

    Draft TG Metal Release 15Feb 2021 EC

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  • 13-November-2020

    English

    The costs and benefits of regulating chemicals

    The OECD has set up the SWACHE project to establish internationally comparable values for the willingness-to-pay (WTP) to avoid negative health effects due to exposure to chemicals. The health effects valued include asthma, fertility loss, IQ loss, chronic kidney disease, and very low birth weight.

  • 12-November-2020

    English

    OECD Work Related to Endocrine Disrupters

    The OECD has published the Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.

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  • 2-November-2020

    English

    Biological pesticides

    The programme (or BioPesticides including microbials - bacteria, algae, protozoa viruses, fungi -, pheromones and semiochemicals, macrobials/invertebrates such as insects and nematodes, and plant extracts/botanicals) helps member countries to harmonise the methods and approaches used to assess biological pesticides.

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  • 29-June-2020

    English

    Test No. 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals

    This Test Guideline describes in vitro assays, which use Androgen Receptor TransActivation (ARTA) to detect Androgen Receptor Agonists and Antagonists. The ARTA assay methods are mechanistically and functionally similar test methods that provide information on the transcription and translation of a reporter gene following the binding of a chemical to the androgen receptor and subsequent transactivation. The cell lines used in these assays express AR and have been stably transfected with an AR-responsive luciferase reporter gene, and are used to identify chemicals that activate (i.e. act as agonist) or inhibit (i.e. act as antagonists) AR-dependent transcription. Some chemicals may, in a cell type-dependent manner, display both agonist and antagonist activity and are known as selective AR modulators. The AR is activated following ligand binding, after which the receptor-ligand complex binds to specific DNA responsive elements and transactivates the receptor gene, resulting in an increase cellular expression of the luciferase enzyme. The enzyme then transforms the substrate to a bioluminescent product that can be quantitatively measured with a luminometer. This Test Guideline includes ARTA assays using the AR-EcoScreenTM cell line, the AR-CALUX® cell line, and 22Rv1/MMTV_GR-KO cell line.
  • 29-June-2020

    English

    Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

    This Test Guideline describes a cytotoxicity-based in vitro assay that is performed on a confluent monolayer of Statens Seruminstitut Rabbit Cornea (SIRC) cells, cultured on a 96-well polycarbonate microplate. After five-minute exposure to a test chemical, the cytotoxicity is quantitatively measured as the relative viability of SIRC cells using the MTT assay. Decreased cell viability is used to predict potential adverse effects leading to ocular damage. Cell viability is assessed by the quantitative measurement, after extraction from the cells, of blue formazan salt produced by the living cells by enzymatic conversion of the vital dye MTT, also known as Thiazolyl Blue Tetrazolium Bromide. The obtained cell viability is compared to the solvent control (relative viability) and used to estimate the potential eye hazard of the test chemical. A test chemical is classified as UN GHS Category 1 when both the 5% and 0.05% concentrations result in a cell viability smaller than or equal to (≤) 70%. Conversely, a chemical is predicted as UN GHS No Category when both 5% and 0.05% concentrations result in a cell viability higher than (>) 70%.
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