Share

Risk management of chemicals

Substitution and alternatives assessment tools and data sources

 

This page compiles information on online resources and softwares that can be used in conducting chemical substitutions or alternatives assessments. It lists:

  • Tools that provide users with the ability to evaluate a chemical, material, process, product and/or technology for attribute analysis with an alternatives assessment, and
  • Data sources, which contain a repository of organised information but no mechanism for data manipulation for outside users. All tools and data sources included address chemical hazard assessment, and may address other comparative attributes.

 

Tools

 Column model

Column Model

The Column Model was developed by the Institute for Occupational Safety and Health (IFA) of the German Social Accident Insurance as a tool for industry for identifying alternative substances. The tool allows for the comparison on chemicals/substances or materials/mixtures based on six hazard endpoints. Endpoints are compared individually and collectively, and the user makes the final evaluation.

Applicability:

For chemical/substance and material/mixture substitutions

The Column Model can be used for assessing alternative chemicals/substances or materials/mixtures and minor process changes. The Column Model is not intended for robust process change evaluations.

Hazard endpoints:

Evaluates the following under GHS guidelines:

Human Health Hazards
• Exposure potential
• Acute health hazards
• Chronic health hazards

Environmental Hazards

Chemical/Physical Properties
• Physicochemical hazards
• Process-related hazards

Green chemistry logo 

Green Chemistry Assistant

The Green Chemistry Assistant allows users to manipulate and assess chemical reactions by determining atom economy, limiting reactant, theoretical yield, percent yield, and comparing chemical safety data. This tool is based on U.S. EPA's Green Chemistry Expert System SMART Module.

Applicability:

For chemical substitutions and process modifications

Hazard Endpoints:

The user can compare hazards based on internal MSDS and NFPA databases and data from the Green Chemistry Expert System (via an internal link).

 Greenscreen logo

GreenScreen® for Safer Chemicals

GreenScreen® was developed by Clean Production Action to support the transition to safer chemicals and to support more informed decision-making on the use of chemicals in products and processes. GreenScreen® provides a rigorous comparative hazard assessment for evaluating alternatives to chemicals of concern based upon 18 hazard endpoints.

Applicability: 

For chemical/substance substitutions

GreenScreen® can be used to compare organic, inorganic, and polymeric chemicals/substances and materials/mixtures. GreenScreen® is only intended for chemical hazard assessments.

Hazard Endpoints:

Human Health Hazards
• Human health group 1 (carcinogenicity, developmental toxicity, endocrine activity, mutagenicity and genotoxicity, reproductive toxicity)
• Human health group 2 (acute mammalian toxicity, systemic toxicity and organ effects, eye irritation, neurotoxicity, respiratory sensitization, skin irritation, skin sensitization)

Environmental Hazards
• Acute aquatic toxicity
• Chronic aquatic toxicity

Environmental Fate
• Bioaccumulation
• Persistence

Chemical/Physical Properties
• Flammability
• Reactivity

 Greenscreen logo

GreenScreen® List Translator (GSLT)

GSLT was developed by Clean Production Action as a rapid screening assessment tool for chemical substances. The screening evaluation results in three outcomes: of high concern, possibly of high concern, and unknown. GSLT is meant to prioritize chemicals for a more comprehensive assessment using the full GreenScreen® method.

Applicability: 

For chemical/substance substitutions

GSLT can be used for identifying chemicals/substances that should be avoided. GSLT is not intended for fully evaluating the relative "safety" of chemicals/substances or alternatives not on authoritative lists.

Hazard Endpoints: 

Human Health Hazards
• Human health group 1 (carcinogenicity, developmental toxicity, endocrine activity, mutagenicity and genotoxicity, reproductive toxicity)
• Human health group 2 (acute mammalian toxicity, systemic toxicity and organ effects, eye irritation, neurotoxicity, respiratory sensitization, skin irritation, skin sensitization)

Environmental Hazards
• Acute aquatic toxicity
• Chronic aquatic toxicity

Environmental Fate
• Bioaccumulation
• Persistence

Chemical/Physical Properties
• Flammability
• Reactivity

 

 KEMI

KemI PRIO

PRIO was developed by the Swedish Chemical Inspectorate (KemI) to help eliminate high hazard chemicals from products to meet the Swedish government's goal of a "non-toxic environment" by 2020. PRIO contains a database of chemicals of high concern to human health and the environment, which are divided into "phase-out" or "priority risk reduction" chemicals. “Phase-out” chemicals should be avoided or substituted, and the tool provides a seven step process for identifying safer alternatives. For “priority risk reduction” chemicals, further assessments are recommended to ensure risk minimization.

Applicability: 

For chemical/substance substitutions

PRIO can be used to identify very hazardous chemicals, prioritize chemicals for elimination and risk reduction, and evaluate alternatives. PRIO is not intended as a definitive guide for safer alternatives.

Hazard Endpoints: 

Human Health Hazards
• Acute and chronic toxicity
• Allergenicity
• Carcinogenicity, mutagenicity, and reproductive toxicity
• Endocrine disruption

Environmental Hazards
• Aquatic toxicity
• Metals (Hg, Cd, Pb, and compounds)
• Ozone depletion

Environmental Fate
• PB and vPvB substances

 

 MaterialQ

MaterialIQ 

MaterialIQ was developed to serve as a product design tool and as a product database of third party certified products. Users can select different methods for human health and ecotoxicity evaluations: GreenScreen List Translator, Scivera Lens or GreenScreen. Product evaluations can also be designed per criteria of a specific ecolabel. MaterialIQ was developed to improve transparency of hazard material usage throughout the supply chain.

Applicability: 
For chemical and product substitutions

 

Hazard Endpoints: 
Physiochemical properties, and human and environmental health hazard endpoints are defined by evaluation methodology selected by user

 US EPA logo

OncoLogic 8.0 

OncoLogic 8.0 is a Windows software tool that predicts the potential carcinogenicity of metals, polymers, fibers, and organic chemicals. Evaluation is based upon structure activity relationship (SAR) analysis and a compilation of cancer data on 1,500 chemicals. This tool is intended to provide data on chemicals for which little or none exists.

Applicability: 
For chemical and process modifications

Hazard Endpoints: 
Human toxicology

 TURI logo

Pollution Prevention Options Analysis System (P2OASys)

P2OASys was developed by the Toxic Use Reduction Institute (TURI) at the University of Massachusetts, Lowell to help companies assess unforeseen consequences of current alternative technologies. P2OAsys allows companies to assess environmental, worker, and public health impacts from alternative technologies. The tool automatically compares current processes to alternatives based on 11 endpoints using an aggregated score, which is dependent upon the proportion of chemical present.

Applicability: 

For chemical/substance, material/mixture, and product/article substitutions and process modifications

P2OASys can be used to compare alternatives based upon process changes. P2OASys is not intended for conducting complete life-cycle assessments.

Hazard Endpoints:

Human Health Hazards
• Acute human effects
• Chronic human effects
• Exposure potential

Environmental Hazards
• Aquatic hazards
• Atmospheric hazards
• Disposal hazards
• Energy and resource use

Environmental Fate
• Bioaccumulation
• Persistence

Chemical/Physical Properties
• Chemical hazards
• Physical hazards
• Product hazards

These endpoints allow an evaluation of materials management strategies, and also basic components of life-cycle analyses

 

 US EPA logo

Program for Assisting the Replacement of Industrial Solvents (PARIS III)

PARIS III was developed by the United States Environmental Protection Agency as a software tool to assist users in finding mixtures of solvents with specific properties that have reduced environmental impacts. Many solvents currently used in industrial processes have negative environmental impacts. PARIS III is designed to encourage technicians, engineers, and consultants to add more benign solvents to harmful ones to reduce the overall environmental impact without the need for equipment updates.

Applicability: 
For chemical/substance, material/mixture, and product/article substitutions and process modifications

Hazard Endpoints: 

• Human toxicity potential (ingestion)
• Human toxicity potential (inhalation)
• Human toxicity potential (dermal)
• Exposure aquatic toxicity potential
• Global warming potential
• Ozone depletion potential
• Photochemical oxidation potential
• Acid rain potential

Also contains LCA component.

 

 QCAT logo

Quick Chemical Assessment Tool (QCAT)

Using GreenScreen® as a blueprint, QCAT was developed by the Washington State Department of Ecology to function as a simpler tool for smaller businesses. QCAT is a screening tool for evaluating chemicals/substances to determine their degree of toxicity and assess alternatives. Chemicals are rated based on an aggregated score of nine hazard endpoints, but relative toxicities can also be assessed based on individual endpoints.

Applicability: 

For chemical/substance substitutions

QCAT is not intended as a comprehensive chemical evaluation or for evaluating materials/mixtures, products/articles, or process modifications

Hazard Endpoints:

QCAT hazard endpoints are based on GreenScreen®:

Human Health Hazards
• Human Health Group 1 (carcinogenicity, developmental toxicity, endocrine activity, mutagenicity and genotoxicity, reproductive toxicity)
• Human Health Group 2 (acute mammalian toxicity)

Environmental Hazards
• Acute aquatic toxicity

Environmental Fate
• Bioaccumulation
• Persistence

 

 SCIVERA logo

SCIVERA LENS Chemical Safety Assessment System 

This tool provides automated restricted substance list (RSL) review, hazard evaluation, exposure assessment (human health and environmental) and risk assessment over the life cycle of the product. As a tool for an alternatives assessment, user can process potential substitutes through the RSL, hazard, exposure, and risk steps to identify preferred alternatives. Scivera was developed for secure supplier product chemical data collection and comprehensive product evaluation.

Applicability: 
For chemical/substance, material, and product substitutions and process modifications

Hazard Endpoints: 
15 human health endpoints and 6 environmental endpoints

 SINLIST logo

SIN List and SINimilarity

The SIN List is an NGO List suggesting substances fulfilling REACH criteria for being “Substances of Very High Concern” (SVHCs). To date, the SIN List consists of some 800 CAS numbers divided into 31 groups. In the SIN List database, for every substance, there is information on hazardous properties, EU regulatory status, producing companies and production volume. When applicable, it also links to substitution case stories. SINimilarity is available through the SIN List database and can identify substances that are structurally similar to SIN List substances. The tool indicates whether the searched substance contains the same group-specific structural elements as SIN List substances and/or if it has structural similarity to any SIN List substances. SINimilarity includes a reference database of 80,000 substances that have been pre-registered under REACH.

Applicability: 
For chemical/substance substitutions

Hazard Endpoints: 

• Endocrine disruption
• Equivalent level of concern
• Carcinogenicity
• Mutagenicity
• Reproductive toxicity
• PBT/vPvB
• Additional information on EU risk/hazard phrases

 UBA logo

SubSelect

The German Federal Environmental Agency's “Guide on Sustainable Chemicals” helps manufacturers, formulators, or end users of substances to put a greater emphasis on sustainability aspects in the selection of substances and use of chemicals. The guide furthermore assists companies in the implementation of the REACH task on the safe use of substances. With the Access-based file SubSelect, an electronic version of the guide is now available. SubSelect assists users in evaluating the sustainability of substances and mixtures.

Applicability: 
For chemical substitutions

Hazard Endpoints:

• Physiochemical properties
• Human health hazards
• Skin, eye, and respiratory hazards
• Ecotoxicity
• Environmental fate/pathways

 

 UL The Wercs logo

UL The Wercs™

UL The Wercs™ is a screening tool for product evaluation. The evaluation can be as complex as the user desires as the user selects the type and number of hazard endpoints/impacts to be evaluated: the user tailors the model. Multiple products can be compared graphically. The tool evaluates the products based on the presence of “chemicals of concern” in the product. The basis of chemicals of concern are “authoritative lists” or restricted substance lists developed by industry.

Applicability: 
For chemical, material, and product substitutions

Hazard Endpoints: 
GreenScreen Endpoints are the basis for UL The Wercs™. Existing internal databases include: toxicological, environmental, physio-chemical properties, technical feasibility.

 

Data sources

 

 Logo Cameo Chemicals

CAMEO Chemicals

CAMEO Chemicals is a database of hazardous chemicals that contains safety and exposure information for emergency responders and planners so they can use to get response recommendations and predict hazards, such as explosions, chemical fires and predicted results from chemical mixtures. It is part of the CAMEO software suite and is available in both online and desktop versions.

Applicability:

For chemical substitutions

Hazard endpoints:

• Physiochemical properties
• Human health hazards 

 Logo Chemical Entities of Biological Interest (ChEBI)

Chemical Entities of Biological Interest (ChEBI)

Chemical Entities of Biological Interest (ChEBI) is a database of molecular entities focused on ‘small’ chemical compounds with potential pharmacological properties. The database consists of records including products of nature or synthetic products used to intervene in the processes of living organisms.


Applicability:

For chemical substitutions

Hazard Endpoints:

• Physiochemical properties

 

 Logo Chemicalize

Chemicalize

Chemicalize was developed by ChemAxon and contains structural and physiochemical data on chemicals, which includes molecular properties.

Applicability: 

For chemical substitutions

 

Hazard Endpoints:

• Physiochemical properties

 logo ChemicALL

ChemicALL

ChemicALL is a database of hazardous chemicals used by members of the Swedish Chemicals Group in the electronics and textile industries. All chemicals contained in the database have been identified as hazardous per authoritative sources. ChemicALL also identifies human health and environmental impacts, as well as authoritative "chemicals of concern" lists that contain a specific chemical.

 

Applicability: 

For chemical/substance and material/mixture substitutions

 

Hazard Endpoints: 

• Human health and environmental impacts

 ChemSec Marketplace

ChemSec Marketplace

ChemSec Marketplace is a business-to-business (B2B) website where buyers and sellers of safer alternatives to hazardous chemicals can interact. The Marketplace is designed with two goals in mind: to provide a unique marketing opportunity for producers of safer alternatives, and to become a one-stop shop for downstream user companies looking to substitute hazardous chemicals in their products.

 

Applicability: 

For chemical/substance substitutions

 

Hazard Endpoints: 

• None

 

 ChemSec Marketplace

ChemSec Textile Guide

ChemSec Textile Guide is a starting point for small and medium-sized textile companies to manage the chemicals present in their processes and products.

 

Applicability: 
For chemical substitutions

 

Hazard Endpoints: 

• None

 

 logo ChemSpider

ChemSpider 

EPA developed ChemView in 2013 to increase the availability of information on chemicals in order to strengthen the existing chemicals program and improve access to and usefulness of chemical data and information. ChemView assists users in getting information on chemical health and safety data and on EPA’s assessments and regulatory actions for specific chemicals under the Toxic Substances Control Act (TSCA). It also contains information EPA receives and develops about chemicals that end up on EPA’s Safer Chemical Ingredients List.

Applicability: 
For chemical substitutions

Hazard Endpoints: 

• Toxicity 
• Physiochemical properties

 Logo EPA

ChemView 

EPA developed ChemView in 2013 to increase the availability of information on chemicals in order to strengthen the existing chemicals program and improve access to and usefulness of chemical data and information. ChemView assists users in getting information on chemical health and safety data and on EPA’s assessments and regulatory actions for specific chemicals under the Toxic Substances Control Act (TSCA). It also contains information EPA receives and develops about chemicals that end up on EPA’s Safer Chemical Ingredients List.

Applicability: 

For chemical substitutions

 

Hazard Endpoints:

• Ecotoxicity (acute aquatic toxicity, chronic aquatic toxicity)
• Environmental fate (bioaccumulation/bioconcentration, PBT designation, persistence, transport, monitoring, other fate)
• Human health (acute toxicity, carcinogenicity, cardiac sensitization, dermal irritation, developmental toxicity, eye irritation, immunotoxicity, lung toxicity, metabolism and pharmacokinetics, mutagenicity/genetic toxicity, neurological toxicity, repeated dose toxicity, reproductive toxicity, respiratory sensitization, skin sensitization, systemic toxicity, other health effect study)
• Physical-chemical properties (boiling point, dissociation constant, melting point, molecular weight, octanol water partition coefficient, physical state description, vapor pressure, water solubility)

 

 Logo CleanGredients

CleanGredients

CleanGredients® was developed by GreenBlue® to help cleaning product formulators identify environmentally friendly ingredients and allow manufacturers to showcase their ingredients. CleanGredients® is a subscription-based online database with 17 cleaning product ingredient categories including: chelating agents, colorants, defoamers, enzymes, fragrances, oxidants, solvents, starter formulations, surfactants, and more. Non-subscribers have partial access to website information. Ingredient formulation and attribute claims are verified by an approved third-party.

 

Applicability: 
For chemical/substance, material/mixture, and product/article substitutions 

CleanGredients® can be used to select products that pass established environmental and health criteria. CleanGredients® is not intended for making definitive comparisons between products.

 

Hazard Endpoints: 

Each product category has defined criteria that must be passed to be listed in CleanGredients®, including characteristics based on U.S. EPA's Design for the Environment's Criteria for Safer Chemical Ingredients. For additional information, please refer to the CleanGredients® Features.

Identifies the following hazard endpoints:
• Human Health Hazards
• Environmental Hazards
• Environmental Fate
• Chemical/Physical Properties

 Logo CPCN

Compendium of Pesticide Common Names

For purposes of trade, registration and legislation, and for use in popular and scientific publications, pesticides need names that are short, distinctive, non-proprietary and widely-accepted. More than 1100 of these official common names for pesticides have been assigned by the International Organization for Standardization (ISO). This Compendium is believed to be the only place where all of the ISO-approved standard names of chemical pesticides are listed. The Compendium contains much more than ISO common names, with nomenclature data sheets for more than 1700 different active ingredients and for more than 350 ester and salt derivatives.

Applicability: 

For chemical/substance substitutions

Hazard Endpoints:

• Activity

 Logo DrugBank

DrugBank

The DrugBank database provides records on "small" chemicals with potential pharmacological or bioactive properties. The database contains 8232 drug entries including 2004 FDA-approved small molecule drugs, 221 FDA-approved biotech (protein/peptide) drugs, 93 nutraceuticals and over 6000 experimental drugs.

Applicability: 

For chemical substitutions 

Hazard Endpoints: 

• Toxicity
• Flashpoint

 Logo eChemPortal

eChemPortal

A searchable database for obtaining many properties of chemicals: physiochemical properties, toxicity, ecotoxicity, and environmental fate/pathways. The first tier of results provides references to external data. The user must access these external sources for data.

Applicability: 

For chemical/substance, material/mixture, and product/article substitutions and process modifications

Hazard Endpoints: 

• Physiochemical properties
• Toxicity
• Ecotoxicity
• Environmental fate/pathways

 Logo EPA

Ecotox

The ECOTOX database combines three previously independent databases (AQUIRE, PHYTOTOX, and TERRETOX) into a single resource for chemical toxicity information on aquatic life, terrestrial plants, and terrestrial wildlife.

Applicability: 

For chemical substitutions

Hazard Endpoints:

• Toxicity

 

 Logo EPA

EPA's substance Registry Service Database 

EPA's Substance Registry Service Database makes it possible to identify which EPA data systems, environmental statutes, or other sources have information about a substance and which synonym is used by that system or statute. It becomes possible therefore to map substance data across EPA programs regardless of synonym.

Applicability: 

For chemical substitutions

Hazard Endpoints: 

• Human health effects, program and regulatory information

 Column model

GESTIS Substance Database

The GESTIS-Substance Database was developed by the Institute for Occupational Safety and Health of the German Social Accident Insurance in Sankt Augustin Germany and contains information on toxicological, ecotoxicological, physiochemical properties, occupational health/first aid, handling/usage and associated European regulations.
 

Applicability: 

For chemical substitutions

Hazard Endpoints: 

• Physiochemical properties
• Toxicity

 Logo Granta Granta

Granta is a tool for materials selection and includes information on physio-chemical and engineering properties, processing, environmental impacts, costs and performance; life cycle impacts can also be evaluated. This tool also contains a database of restricted substances that was developed by NGOs, governments and industry. Materials selection information is contained in several different modules.

Applicability: 

For material substitutions and process modifications

Hazard Endpoints: 

• Physiochemical properties

 Logo King County

Hazardous Chemicals in Schools Database

 

The Hazardous Chemicals in Schools Database was developed by the Local Hazardous Waste Management Program in King County, WA, primarily for the handling of hazardous chemicals commonly used in schools. This online tool provides information to help assess risks and inventory chemicals. The user can find the chemical by name, the exposure and safety hazards, environmental toxicity, and common experiments that may use the chemical.

Applicability: 

For process modifications

Hazard Endpoints: 

• Toxicity
• Flammability

 Logo Haz-Map

Haz-Map

 

Haz-Map is an occupational health database designed for health and safety professionals and for consumers seeking information about the adverse effects of workplace exposures to chemical and biological agents. Chemical records include formula, synonyms, description, uses, exposure assessment, adverse effects, and links to TOXNET and ChemIDPlus.

Applicability: 

For chemical substitutions

Hazard Endpoints: 

• Toxicity

 ‌‌‌Logo EPA

Integrated Risk Information System (IRIS)

 

EPA's Integrated Risk Information System (IRIS) is a human health assessment program that evaluates information on health effects (cancerous and non-cancerous) that may result from exposure to environmental contaminants. The IRIS database contains information that can be used to support the first two steps (hazard identification and dose-response evaluation) of the risk assessment process.

Applicability: 

For chemical substitutions

Hazard Endpoints: 

• Toxicity
• Carcinogenicity

 INCHEM

IPCS INCHEM

 

IPCS INCHEM was developed by IOMC and consolidates current, internationally peer-reviewed chemical safety-related publications and database records from international bodies for public access.

Applicability: 

For chemical substitutions

Hazard Endpoints: 

• Human/animal toxicity
• Ecotoxicity
• Carcinogenicity
• Mutagenicity
• Environmental fate/pathways
• Physiochemical properties

 ‌‌‌Logo OSHA

OSHA Occupational Chemical Database

 

The OSHA Occupational Chemical Database was developed by OSHA and EPA as a convenient reference for the occupational safety and health community. It compiles information from several government agencies and organizations. Information available in the report includes physical properties, exposure, worker safety data, and emergency response information.

Applicability: 

For chemical substitutions

Hazard Endpoints: 

• Physiochemical properties
• Reactivity
• Toxicity

 ‌‌‌Logo Pharos

Pharos Project

 

This datasource is for building materials evaluations, and is divided into three parts: building materials library, chemical/materials library and certification information. The building materials library contains products that are scored in 5 categories (see Hazard Endpoints) separately (no aggregate score). The chemical and materials library rates each entry on individual health and environmental impacts throughout their lifecycle (if applicable). However, no aggregate score is calculated. Also, not every entry contains comprehensive data. Pharos also contains a searchable database of second and third party certifications and identifies building products that have been certified; certification is one criterion in the scoring system.

Applicability: 

For chemical/substance, material/mixture, and product/article substitutions

Hazard Endpoints: 

GreenScreen or GreenScreen List Translator are used to evaluate hazard impacts of most of the materials:
• Human health hazards
• Environmental hazards
• Environmental fate
• Chemical/physical properties

Materials and products are scored on VOC emissions during usage, toxic chemical content usage and, manufacturing, renewable material potential energy used throughout its lifecycle, and reflectance (for roofing products). Chemicals are rated via their physiochemical, toxicological and ecotoxicological properties. Pharos evaluates other impacts and includes external data sources if available. Forest and biobased products are also evaluated on their impact to endangered species.

 ‌‌‌Logo RISCTOX

RISCTOX

RISCTOX was developed by the Spanish Trade Union Institute of Health, Work and Environment (ISTAS) and the European Trade Union Institute (ETUI) and is based on European environmental and health standards. The tool includes over 100,000 chemicals, providing information on substance classification and labeling under EU Regulation 1272/2008, health and environmental impacts and risks, and environmental and health regulations. Users can search by hazard endpoint or specific substance.

 

Applicability: 

For chemical/substance substitutions

RISCTOX also provides a list of priority chemicals of concern.

Hazard Endpoints:

Human Health Hazards
• Carcinogenicity/mutagenicity
• Endocrine disruption
• Neurotoxicity
• Sensitization
• Ototoxicity
• Occupational disease related
• Reproductive toxicity

Environmental Hazards
• Aquatic toxicity
• Atmospheric pollutants
• Soil pollutants

Environmental Fate
• Persistence, bioaccumulation, toxicity (PBT)
• Persistent organic pollutants (POP)

Chemical/Physical Properties
• Volatile organic compounds (VOC)

 ‌‌‌‌Logo Safer Chemical Ingredients List (SCIL)

Safer Chemical Ingredients List (SCIL)

The EPA Safer Choice program was designed to help businesses and consumers make better purchasing decisions by labeling products that have been screened using stringent criteria for health and environmental safety. The Safer Chemical Ingredients List (SCIL) website lists chemicals that meet the criteria of the Safer Choice program. This list of safer chemical ingredients is arranged by 16 functional-use classes and can assist product manufacturers in identifying chemicals that the Safer Choice program has already evaluated and identified as safer. A list of products with the Safer Choice label, organized by consumer and Industrial and Institutional product categories, can also be accessed from the SCIL website.

Applicability: 

For chemical/substance, material/mixture, and product/article substitutions

Hazard Endpoints:

Chemicals, materials and products are evaluated based the Master Criteria that include the following considerations:

• Acute mammalian toxicity
• Carcinogenicity
• Genetic toxicity
• Neurotoxicity
• Repeated dose toxicity
• Reproductive and developmental toxicity
• Respiratory sensitization
• Environmental toxicity and fate
• Eutrophication

Certain categories of chemicals and products include evaluation endpoints not included in the Master Criteria (e.g. chelating and sequestering agents have skin sensitization considerations, fragrances have photosensitization considerations, and inorganic or mineral-based products have recycled content and performance considerations).

 ‌‌‌‌‌Logo TOXNET

TOXNET

TOXNET is a comprehensive collection of databases managed by the National Institutes of Health that provide data and references for hundreds of thousands of potentially hazardous chemicals. Entering a chemical ID or associated hazards into the search field cross-references and returns results from the following databases: TOXLINE, ChemIDplus, Developmental and Reproductive Toxicology Database (DART), Carcinogenic Potency Database (CPDB), GENE-TOX, Comparative Toxicogenomics Database (CTD), Chemical Carcinogenesis Research Information System (CCRIS), and International Toxicity Estimates for Risk (ITER).

Applicability: 

For chemical substitutions

Hazard Endpoints:

• Physiochemical properties
• Human health hazards
• Skin, eye, and respiratory hazards
• Exposure
• Mutagenicity
• Carcinogenicity
• Animal toxicity
• Ecotoxicity
• Environmental fate/pathways

 ‌‌‌‌‌‌Logo ZINC12

ZINC12

ZINC12 was developed by the University of California, San Francisco and is a database of chemical and structural properties consisting of over 35 million compounds that can be screened for biological relevance. ZINC12 includes over 200 catalogs from over 100 vendors and over 40 annotated catalogs.

Applicability: 

For chemical substitutions

Hazard Endpoints:

• Physiochemical properties
• Animal toxicity
• Ecotoxicity

ENGAGE WITH US

 

 

Related Documents