The characteristics of innovative start-up firms in South Tyrol, the northernmost province of Italy, entirely mountainous, hosting a high-income population belonging to three main language groups. This work is part of a series of thematic papers on sub-national start-up landscapes in Italy, produced by the OECD Trento Centre for Local Development. It represents a first attempt to analyse the effect of the Italian policy framework for young innovative firms at the local level. South Tyrol is home to a relatively small number of registered innovative start-ups, pointing to the presence of obstacles to policy transfer. Evidence suggests that language barriers may play a critical role. Firm dynamism, in particular high-growth and exit trends, the spread of emerging technologies among local start-ups as well as their propensity to uptake national incentives are other major focuses of this work, which concludes with a set of evidence-based recommendations for policy-makers.