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  • 30-September-2022

    English

    Series on Testing and Assessment: publications by number

    The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of Integrated Approaches for Testing and Assessment (IATA). The objective is to increase experience with the use of IATA by developing case studies, which constitute examples of predictions that are fit for regulatory use.

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  • 27-September-2022

    English

    Webinar Series on Testing and Assessment Methodologies

    27 September 2022 at 14:00 (CEST) | The OECD is organising a webinar on the first stand-alone Non-Animal Methods (NAMs) for eye hazard identification into OECD guidelines: GL No. 467 and test No. 492b. This webinar aims to increase the awareness of these newly adopted guidelines for regulatory acceptance and to recognise the efforts of the organisation, as well as its stakeholders to commit to 3R principles for chemical hazard testing

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  • 14-September-2022

    English

    Emission Scenario Documents

    This OECD Emission Scenario Document (ESD) is intended to provide information on emissions of metals during primary and secondary smelting and waste incineration, which cover recycling of electrical and electronic waste. It thus aims to derive the relevant emission factors of metals during smelting, waste incineration and from boilers.

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  • 9-September-2022

    English

    Series on Risk Management - Publications by number

    The series on Risk Management covers methodologies for both governments and industry to manage risks posed by chemicals and, when appropriate, to harmonise risk management activities. The OECD provides information on the following areas: perfluorinated chemicals, substitution of hazardous chemicals, sustainable chemistry and others.

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  • 25-July-2022

    English

    Safety of novel foods and feeds and on the harmonisation of regulatory oversight in biotechnology

    These two documents compile information on activities related to the assessment of the safety of products derived from modern biotechnology, environmental safety (biosafety) and the safety of novel foods and feeds, at the international level between April 2021 and May 2022. The information was provided by OECD Members, partner countries and observer organisations participating in the work.

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  • 11-July-2022

    English

    Publications in the series on chemical accidents

    A new report aims to investigate safety issues related to the prevention of, preparedness for, and response to accidents involving manufactured nanomaterials. Available information, guidelines, and seven accident cases are analysed for raising awareness of chemical safety policymakers on the potential risks of chemical accidents involving nanomaterials and reviewing measures to prevent them.

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  • 30-June-2022

    English

    OECD Biotechnology Update

    Read our newsletter to stay up-to-date with all the latest OECD work on biotechnology.

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  • 30-June-2022

    English

    Test No. 442D: In Vitro Skin Sensitisation - ARE-Nrf2 Luciferase Test Method

    The present Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. The second key event on the adverse outcome pathway leading to skin sensitisation takes place in the keratinocytes and includes inflammatory responses as well as gene expression associated with specific cell signalling pathways such as the antioxidant/electrophile response element (ARE)-dependent pathways. The test method described in this Test Guideline (ARE-Nrf2 luciferase test method) is proposed to address this second key event. The cell line contains the luciferase gene under the transcriptional control of a constitutive promoter fused with an ARE element from a gene that is known to be up-regulated by contact sensitisers. The luciferase signal reflects the activation by sensitisers of endogenous Nrf2 dependent genes. This allows quantitative measurement (by luminescence detection) of luciferase gene induction, using well established light producing luciferase substrates, as an indicator of the activity of the Nrf2 transcription factor in cells following exposure to electrophilic test substances. There are currently two in vitro ARE-Nrf2 luciferase test method covered by this Test Guideline: the KeratinoSensTM test method and the LuSens test method. Performance standards have been developed to enable the validation of similar test methods.
  • 20-June-2022

    English

    Section 4: Health Effects

    Interested parties are invited to send their comments on the following Draft Test Guideline No. 442C on In Chemico Skin Sensitisation: Draft updated Appendix I: Direct Peptide Reactivity Assay (DPRA). Comments should be sent by 20 June 2022.

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  • 15-June-2022

    English

    Draft Guidance and Review Documents/Monographs

    Interested parties are invited to send their comments on the Draft Guidance on Evaluation of Data from the Developmental Neurotoxicity (DNT) In-Vitro Testing Battery on 15 June 2022.

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