Regions and Cities at a Glance 2020 provides a comprehensive assessment of how regions and cities across the OECD are progressing towards stronger, more sustainable and more resilient economies and societies. The publication provides a unique comparative picture in a number of aspects connected to economic development, health, well-being and net zero-carbon transition across regions and cities in OECD and selected non-OECD countries. In the light of the health crisis caused by the COVID-19 pandemic, the report analyses outcomes and drivers of social, economic and environmental resilience. This edition provides several new features. First, an extended set of health-related indicators, including excess mortality, morbidity rates, and air quality. Second, novel indicators on the potential of regions and cities to remote working, as well as on trade openness and access to digital infrastructure enrich the economic chapter. Third, the report offers a number of new climate-and environment-related indicators, including on sustainable electricity production and related carbon emissions. The report shows population trends in over nine thousands cities and metropolitan areas across the entire world. Finally, the last chapter presents new indicators on spending and revenues capacity of regional governments in OECD countries.