This Overview Guidance Document summarises the major guidance aspects provided in the OECD Guidelines for the Testing of Chemicals, Section 5. This document also develops an approach for a Global Maximum Residue Limit (MRL) process to achieve use of a single globally acceptable feeding study for MRL setting and risk assessment for livestock food commodities that involves four key components: 1) Harmonised Guidance for the Definition of Residue; 2) Reasonable Worst Case Animal Diets/Maximum Reasonably Balanced Diet; 3) Harmonised Table of Livestock Feed Commodities; and 4) Definition of Reasonable Worst Case Livestock Feeding Levels. Each of these components is described and supported by the following resources: (i) a table of raw agricultural commodities; (ii) national and regional tables of livestock feedstuffs; (iii) a glossary of Terms; (iv) comprehensive submission criteria for supervised field trials in support of registration in all OECD countries; and (v) instructions for calculating the 1x (lowest dose) pesticide oral administration level for livestock feeding studies, taking into account the various livestock diets around the world.