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  • 23-December-2022

    English

    Draft Guidance and Review Documents/Monographs

    Interested parties are invited to send their comments on the Draft Detailed Review Paper on the inclusion of thyroid endpoints in OECD fish tests by 23 December 2022.

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  • 14-December-2022

    English

    Webinar Series on Testing and Assessment Methodologies

    14 December 2022 at 13:00 - 14:30 CET / 07:00 - 08:30 EST | This webinar is highly relevant to all parties involved in regulatory chemical risk assessment, including the increased uptake of mechanistic approaches and New Approach Methodologies (NAMs) supported by AOPs.

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  • 22-November-2022

    English

    Series on Testing and Assessment: publications by number

    The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of Integrated Approaches for Testing and Assessment (IATA). The objective is to increase experience with the use of IATA by developing case studies, which constitute examples of predictions that are fit for regulatory use.

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  • 18-November-2022

    English

    Section 4: Health Effects

    Interested parties are invited to send their comments on the following Draft Test Guideline on in vitro immunotoxicity assay: IL-2 luc assay. Comments should be sent by 18 November 2022.

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  • 11-October-2022

    English

    OECD Good Laboratory Practice: Frequently asked questions (FAQ)

    GLP issues raised by testing labs are covered in this comprehensive list of questions and answers, recently updated with questions related to: Test Facility organisation and personnel, Quality Assurance, Equipment and computerized systems, Test items, reference items and samples/specimens (Biologicals, GMOs, etc.), SOPs, Management of the study, Histopathology, Archives and E-Archives and Monitoring Test Facility compliance by GLP CMAs.

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  • 30-June-2022

    English

    Test No. 442D: In Vitro Skin Sensitisation - ARE-Nrf2 Luciferase Test Method

    The present Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. The second key event on the adverse outcome pathway leading to skin sensitisation takes place in the keratinocytes and includes inflammatory responses as well as gene expression associated with specific cell signalling pathways such as the antioxidant/electrophile response element (ARE)-dependent pathways. The test method described in this Test Guideline (ARE-Nrf2 luciferase test method) is proposed to address this second key event. The cell line contains the luciferase gene under the transcriptional control of a constitutive promoter fused with an ARE element from a gene that is known to be up-regulated by contact sensitisers. The luciferase signal reflects the activation by sensitisers of endogenous Nrf2 dependent genes. This allows quantitative measurement (by luminescence detection) of luciferase gene induction, using well established light producing luciferase substrates, as an indicator of the activity of the Nrf2 transcription factor in cells following exposure to electrophilic test substances. There are currently two in vitro ARE-Nrf2 luciferase test method covered by this Test Guideline: the KeratinoSensTM test method and the LuSens test method. Performance standards have been developed to enable the validation of similar test methods.
  • 21-March-2022

    English

    Webinar Series on Emerging Science to Improve Chemical Safety

    On 16 March, the OECD and the EU Joint Research Centre organised a webinar to discuss the report on Addressing evidence needs in chemicals policy and regulation. It presented the main findings of the report and a set of actionable recommendations, including how knowledge management systems can be designed in a user-centric fashion to address current challenges, with the Adverse Outcome Pathway framework being a prominent example.

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  • 1-December-2021

    English

    Good Laboratory Practice (GLP)

    Read the countries' response to address the challenges posed by COVID-19 to GLP test facilities.

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  • 19-November-2021

    English

    Ongoing Peer Reviews

    Peer review package of the Test Guideline 442C Amino acid Derivative Reactivity Assay (ADRA)

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  • 28-July-2021

    English

    OECD Work Related to Bees/Pollinators

    There have been reports these last years of declines in native and managed pollinators in several regions of the world. Potential factors associated with these declines are hypothesised to include habitat destruction, predators, certain agricultural practices, bee management practices, pathogens, climate change, nutrition and pesticides. There is uncertainty regarding the extent to which pesticides contribute to pollinator declines.

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