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  • 20-June-2022

    English

    Section 4: Health Effects

    Interested parties are invited to send their comments on the following Draft Test Guideline No. 442C on In Chemico Skin Sensitisation: Draft updated Appendix I: Direct Peptide Reactivity Assay (DPRA). Comments should be sent by 20 June 2022.

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  • 15-June-2022

    English

    Draft Guidance and Review Documents/Monographs

    Interested parties are invited to send their comments on the Draft Guidance on Evaluation of Data from the Developmental Neurotoxicity (DNT) In-Vitro Testing Battery on 15 June 2022.

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  • 6-April-2022

    English

    Webinar Series on Testing and Assessment Methodologies

    On 6 April 2022, the OECD organised a second webinar on the application of the assessment framework for Physiologically Based Kinetic (PBK) models. The webinar presented two case studies and illustrated how the templates of the guidance were used to report and evaluate PBK models. A discussion took place on challenges related to the regulatory evaluation of PBK models and clarifications on aims and scope of these models were provided.

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  • 21-March-2022

    English

    Webinar Series on Emerging Science to Improve Chemical Safety

    On 16 March, the OECD and the EU Joint Research Centre organised a webinar to discuss the report on Addressing evidence needs in chemicals policy and regulation. It presented the main findings of the report and a set of actionable recommendations, including how knowledge management systems can be designed in a user-centric fashion to address current challenges, with the Adverse Outcome Pathway framework being a prominent example.

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  • 1-December-2021

    English

    Good Laboratory Practice (GLP)

    Read the countries' response to address the challenges posed by COVID-19 to GLP test facilities.

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  • 19-November-2021

    English

    Ongoing Peer Reviews

    Peer review package of the Test Guideline 442C Amino acid Derivative Reactivity Assay (ADRA)

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  • 19-October-2021

    English

    Series on Testing and Assessment: publications by number

    This Series includes publications related to testing and assessment of chemicals; some of them support the development of OECD Test Guidelines (e.g. validation reports, guidance documents, detailed review papers).

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  • 21-September-2021

    English

    OECD Series on Principles of Good Laboratory Practice (GLP) and Compliance Monitoring

    This OECD Advisory Document on Good Laboratory Practice (GLP) Data Integrity provides guidance for test facilities or test sites that conduct GLP studies and aims to promote a risk-based approach to the management of data.

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  • 28-July-2021

    English

    OECD Work Related to Bees/Pollinators

    There have been reports these last years of declines in native and managed pollinators in several regions of the world. Potential factors associated with these declines are hypothesised to include habitat destruction, predators, certain agricultural practices, bee management practices, pathogens, climate change, nutrition and pesticides. There is uncertainty regarding the extent to which pesticides contribute to pollinator declines.

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  • 17-June-2021

    English

    Test No. 405: Acute Eye Irritation/Corrosion

    This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is applied in a single dose in the conjunctival sac of one eye of each animal. The other eye, which remains untreated, serves as a control. The initial test uses an animal; the dose level depends on the test substance nature. A confirmatory test should be made if a corrosive effect is not observed in the initial test, the irritant or negative response should be confirmed using up to two additional animals. It is recommended that it be conducted in a sequential manner in one animal at a time, rather than exposing the two additional animals simultaneously. The duration of the observation period should be sufficient to evaluate fully the magnitude and reversibility of the effects observed. The eyes should be examined at 1, 24, 48, and 72 hours after test substance application. The ocular irritation scores should be evaluated in conjunction with the nature and severity of lesions, and their reversibility or lack of reversibility. Use of topical anesthetics and systemic analgesics to avoid or minimize pain and distress in ocular safety testing procedures is described.
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