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  • 24-January-2024

    English

    Draft Guidance and Review Documents/Monographs

    Interested parties are invited to send their comments on the Draft revised Guidance Document no 75 on the Honey Bee (Apis mellifera L.) Brood Test under Semi-Field Conditions by 24 January 2024.

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  • 29-November-2023

    English

    Webinar Series on Testing and Assessment Methodologies

    Two webinars were held by the OECD, which aimed to provide training and orientation on method validation at the OECD, and to help researchers become familiar with method readiness evaluation.

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  • 16-November-2023

    English

    Section 4: Health Effects

    Interested parties are invited to send their comments on the Draft Updated TG 467 Part III: Defined Approach on Eye Irritation for Solids by 22 December 2023.

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  • 23-October-2023

    English

    Adverse Outcome Pathways

    The OECD released four new Adverse Outcome Pathways following scientific review and OECD endorsement.

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  • 13-October-2023

    English

    Series on Testing and Assessment: publications by number

    The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of Integrated Approaches for Testing and Assessment (IATA). The objective is to increase experience with the use of IATA by developing case studies, which constitute examples of predictions that are fit for regulatory use.

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  • 20-September-2023

    English, PDF, 4,784kb

    OECD work on Chemical Safety and Biosafety brochure 2021-24

    This new edition of the OECD work on Chemical Safety and Biosafety highlights the activities, results and ongoing projects as outlined by the 2021-2024 work programme.

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  • 19-September-2023

    English

    OECD Work Related to Bees/Pollinators

    There have been reports these last years of declines in native and managed pollinators in several regions of the world. Potential factors associated with these declines are hypothesised to include habitat destruction, predators, certain agricultural practices, bee management practices, pathogens, climate change, nutrition and pesticides. There is uncertainty regarding the extent to which pesticides contribute to pollinator declines.

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  • 18-July-2023

    English

    Good Laboratory Practice (GLP)

    The OECD Principles of Good Laboratory Practice (GLP) ensure the generation of high quality and reliable test data related to the safety of industrial chemical substances and preparations. The principles have been created in the context of harmonising testing procedures for the Mutual Acceptance of Data (MAD).

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  • 12-July-2023

    English

    Ongoing Peer Reviews

    Peer review package of the Test Guideline 442C Amino acid Derivative Reactivity Assay (ADRA)

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  • 4-July-2023

    English

    Test No. 487: In Vitro Mammalian Cell Micronucleus Test

    The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are unable to migrate to the poles during the anaphase stage of cell division. The assay detects the activity of clastogenic and aneugenic test substances in cells that have undergone cell division during or after exposure to the test substance. This Test Guideline allows the use of protocols with and without the actin polymerisation inhibitor cytochalasin B. Cytochalasin B allows for the identification and selective analysis of micronucleus frequency in cells that have completed one mitosis, because such cells are binucleate. This Test Guideline also allows the use of protocols without cytokinesis block provided there is evidence that the cell population analysed has undergone mitosis.   
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