Latest Documents

Draft Guidance and Review Documents/Monographs

Interested parties are invited to send their comments on the Draft Detailed Review Paper on the inclusion of thyroid endpoints in OECD fish tests by 23 December 2022.

Webinar Series on Testing and Assessment Methodologies

14 December 2022 at 13:00 - 14:30 CET / 07:00 - 08:30 EST | This webinar is highly relevant to all parties involved in regulatory chemical risk assessment, including the increased uptake of mechanistic approaches and New Approach Methodologies (NAMs) supported by AOPs.

Series on Testing and Assessment: publications by number

The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of Integrated Approaches for Testing and Assessment (IATA). The objective is to increase experience with the use of IATA by developing case studies, which constitute examples of predictions that are fit for regulatory use.

Section 4: Health Effects

Interested parties are invited to send their comments on the following Draft Test Guideline on in vitro immunotoxicity assay: IL-2 luc assay. Comments should be sent by 18 November 2022.

OECD Good Laboratory Practice: Frequently asked questions (FAQ)

GLP issues raised by testing labs are covered in this comprehensive list of questions and answers, recently updated with questions related to: Test Facility organisation and personnel, Quality Assurance, Equipment and computerized systems, Test items, reference items and samples/specimens (Biologicals, GMOs, etc.), SOPs, Management of the study, Histopathology, Archives and E-Archives and Monitoring Test Facility compliance by GLP CMAs.

Test No. 442D: In Vitro Skin Sensitisation - ARE-Nrf2 Luciferase Test Method

Webinar Series on Emerging Science to Improve Chemical Safety

On 16 March, the OECD and the EU Joint Research Centre organised a webinar to discuss the report on Addressing evidence needs in chemicals policy and regulation. It presented the main findings of the report and a set of actionable recommendations, including how knowledge management systems can be designed in a user-centric fashion to address current challenges, with the Adverse Outcome Pathway framework being a prominent example.

Good Laboratory Practice (GLP)

Read the countries' response to address the challenges posed by COVID-19 to GLP test facilities.

Ongoing Peer Reviews

Peer review package of the Test Guideline 442C Amino acid Derivative Reactivity Assay (ADRA)

OECD Work Related to Bees/Pollinators

There have been reports these last years of declines in native and managed pollinators in several regions of the world. Potential factors associated with these declines are hypothesised to include habitat destruction, predators, certain agricultural practices, bee management practices, pathogens, climate change, nutrition and pesticides. There is uncertainty regarding the extent to which pesticides contribute to pollinator declines.