Testing of chemicals


  • Report: Saving Costs in Chemicals Management - How the OECD Ensures Benefits to Society

    The Saving Costs in Chemicals Management report estimates that the OECD Environment Health and Safety Programme saves governments and industry around EUR 309 million a year. Find out how governments are working together to tackle the risks posed by chemicals.

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  • Guidance Document on Good In Vitro Method Practices (GIVIMP)

    This document provides detailed guidance on good scientific, technical and quality practices to assure the reliability of data derived from cell and tissue based in vitro toxicity test methods. It primarily targets practitioners working in the development and application of in vitro methods and associated Test Guidelines intended for the regulatory safety assessment of chemicals used in different sectors. The project to develop the guidance has been led by the European Commission’s Joint Research Centre (JRC).

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  • Three new publications on Adverse Outcome Pathways

    The first publication describes the linkage between inhibition of complex I of the mitochondrial respiratory chain and motor deficit as in parkinsonian disorders. The second publication links chronic binding of antagonist to N-methyl-D-aspartate receptors during brain development leading to neurodegeneration. The third publication details the linkage between binding and activation of androgen receptor leading to reproductive dysfunction.

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OECD assists countries in harmonising Guidelines for the Testing of Chemicals and Good Laboratory Practice, in order to ensure high quality and reliable data and for countries and industry to fully benefit from the OECD agreement on Mutual Acceptance of Data (MAD) and avoid duplicative testing.


Saving costs in Chemicals Management with the Mutual Acceptance of Data system


Did you know?

By reducing duplication, and creating a framework for the sharing of work, the Mutuall Acceptance of Data system saves governments and industry around € 309 million each year, as well as reduces the number of animals used in such testing. 

Source: Saving Costs in Chemicals Management, OECD (2019).

Key areas of work

> OECD Guidelines for the Testing of Chemicals 

> Good Laboratory Practice

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Saving Costs in Chemicals Management

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Guidance Document on evaluating Chemicals for Endocrine Disruption

 This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.


Guidance Document on Good In Vitro Method Practices (GIVIMP)


 Guidance Document on Good In Vitro Methods Practices (GIVIMP)