Major nuclear regulatory challenges will arise from government policies to liberalise energy sectors. In a context of growing competition and market deregulation, it is becoming increasingly important to reconcile commercial interests with safety requirements. For nuclear regulatory bodies, the first challenge will be to ensure that economic pressures do not erode nuclear safety. In their strive to maintain nuclear safety culture, regulatory bodies will also need to adapt to an increasingly market-oriented environment and new working relationships with operators. This report identifies the challenges that regulators are likely to be confronted with over the next ten years.