Regulator-industry co-operation in nuclear safety research has potential advantages as well as disadvantages. This report provides research managers in industry, regulatory organisations and research centres with information on current practices in collaborative safety research in OECD member countries. It identifies means of establishing effective industry-regulator collaboration and provides indications on how to overcome difficulties that can arise. It also advises on possible areas of concern. The report addresses in particular the issue of regulator independence, means to preserve it and ways to demonstrate it to the public while undertaking collaboration with industry.