In recent years, more attention has been paid to the way gender interacts with intercultural and global learning opportunities. While evidence shows that schools are shaping a gendered citizenry, the notions of citizenship in this research has been notably local with limited focus on global conceptions of citizenship. PISA 2018 asked students a series of questions about their global and intercultural attitudes and dispositions. Those questions focused on the four dimensions of global competence: students’ ability to examine local and global issues, their capacity to understand and appreciate the perspectives of others, their ability to engage in effective communication across cultures, and their willingness to take action for collective well-being and sustainable development. Findings show some important gender differences discussed in this paper.