This document provides guidance on the validation requirements for analytical methods used for pre-registration and monitoring in the context of pesticide authorisation. Analytical methods are used to generate data to estimate dietary exposure, establish Maximum Residue Levels (MRLs), determine processing factors, and assess storage stability. Analytical methods are also used in support of environmental fate studies, efficacy studies, ecotoxicological and toxicological studies (including dose verification), as well as operator, worker, resident, and bystander exposure studies. Analytical methods are also used in enforcement of any statutory MRLs.
First commenting round on the Draft Revised Guidance Document on Pesticide Residue Analytical Methods
- Submission period
- 30 September - 11 November 2025
Background public consultation
Project description
The need for revision of the OECD guidance document became apparent in the context of a recently finalised project at EU level. The former EU Guidance Documents SANCO/3029/99 and SANCO/825/00 for pre- and post-registration analytical methods were updated and merged (now SANTE/2020/12830, Rev.1, issued 24. February 2021). This revision was required to take into account (i) the scientific progress made in analytical method development, (ii) the discussions with applicants and other Member State competent authorities and (iii) the changes of regulatory requirements in the EU. The main objectives were to enhance clarity and improve harmonisation within the EU. The revision of the OECD guidance document is seeking to extend this harmonisation to all OECD member countries.
How to contribute
The draft Revised Guidance Document on Pesticide Residue Analytical Methods is currently under a commenting round by the Working Party of the National Coordinators of the Test Guidelines Programme (WNT) and Working Party on Pesticides (WPP), and open for comments from the public at the same time. Interested parties are invited to submit comments to/contact their National Coordinators at least a week before 23 October 2025.
Documents for public comments
