The project to update Guidance Document 151 follows the update of TG 443 in 2025. The project was led jointly by the European Chemicals Agency, the Netherlands and Denmark.
Commenting round on the draft updated Guidance Document 151 on the implementation of the Extended One-Generation Reproductive Toxicity Study (Test Guideline 443)
- Submission period
- 28 Nov 2025 - 23 Jan 2026
Background public consultation
Project description
More guidance for robust measurements of reproductive endpoints such as nipple retention and anogenital distance has been developed, as well as more guidance on the evaluation of developmental immunotoxicity (TDAR).
How to contribute
The draft updated Guidance Document 151 is currently under a commenting round by the Working Party of the National Coordinators of the Test Guidelines Programmes and open for comments from the public at the same time. Interested parties are invited to contact their National Coordinators at least a week before 23 January 2025.
