As discussed in Section 3.3 of Chapter 3 and 4.3.2 of Chapter 4 a standard outlier exclusion procedure from statistics is chosen to avoid the influence of implausibly high or low VSL estimates. In the general meta-analysis literature, it is often justified to remove an observation that is defined as an outlier in the sense that the upper bound of the 95% confidence interval of the estimate is lower than the lower bound of the pooled mean 95% confidence interval (i.e., extremely small estimates) or the lower bound of the 95% confidence interval is higher than the upper bound of the pooled mean 95% confidence interval (i.e., extremely large estimates) (Viechtbauer and Cheung, 2010[1]).
Figure A E.1 shows the 95% intervals of the meta-analysis estimates using (1) all pooled estimates (N=4 128), (2) the main estimates after removing far-outs (N=3 981), (3) the upper far-out estimates (N=136) based on Tukey's fences, and (4) the lower far-out estimates (N=11). These results indicate that the removal of far-out observations is very conservative and well justified by common practice (Viechtbauer and Cheung, 2010[1]). In fact, the lower bound of the upper far-out is much higher than the upper bound of the pooled estimates (“All”) and the upper bound of the lower far-out is much lower than the lower bound of the pooled estimates (“All”) (cf. Section 4.3.1 of Chapter 4).