Biotechnology – the use of living organisms and their components to generate knowledge and products – has become a cornerstone of innovation across health, agriculture and manufacturing. Beyond biomedical applications, biosolutions are emerging as a major opportunity to address global challenges, from climate change to food security. This policy brief explores the investment and regulatory policy landscapes in the European Union and the United States, highlighting shared challenges and lessons that can help accelerate sustainable innovation and strengthen participation in the global bioeconomy.