This paper develops a methodology for the estimation of Energy Physical Supply and Use Tables (E-PSUTs) based on the IEA’s World Energy Balances (WEB). The tables are similar to those proposed by the United Nations System of Environmental Economic Accounting. However, they fully exploit, and are consistent, with the information on fuel transformation processes available in the WEB. The E-PSUTs can be used to derive energy indicators in physical units. Additionally, they can be used in a hybrid methodological approach to link global energy production and consumption in physical units with global production and consumption in monetary units, allowing the development of indicators to better understand the multiple links between energy and the economy, contributing to climate change discussions. Furthermore, complementary analyses can be undertaken by linking the MF-IO model with variables such as industry value added and employment data. And, used to estimate energy-related CO2 emissions indicators.