Interested parties are invited to send their comments on the following Draft Test Guideline No. 442C on In Chemico Skin Sensitisation: Draft updated Appendix I: Direct Peptide Reactivity Assay (DPRA). Comments should be sent by 20 June 2022.
Interested parties are invited to send their comments on the Draft Guidance on Evaluation of Data from the Developmental Neurotoxicity (DNT) In-Vitro Testing Battery on 15 June 2022.
On 6 April 2022, the OECD organised a second webinar on the application of the assessment framework for Physiologically Based Kinetic (PBK) models. The webinar presented two case studies and illustrated how the templates of the guidance were used to report and evaluate PBK models. A discussion took place on challenges related to the regulatory evaluation of PBK models and clarifications on aims and scope of these models were provided.
On 16 March, the OECD and the EU Joint Research Centre organised a webinar to discuss the report on Addressing evidence needs in chemicals policy and regulation. It presented the main findings of the report and a set of actionable recommendations, including how knowledge management systems can be designed in a user-centric fashion to address current challenges, with the Adverse Outcome Pathway framework being a prominent example.
Peer review package of the Test Guideline 442C Amino acid Derivative Reactivity Assay (ADRA)
There have been reports these last years of declines in native and managed pollinators in several regions of the world. Potential factors associated with these declines are hypothesised to include habitat destruction, predators, certain agricultural practices, bee management practices, pathogens, climate change, nutrition and pesticides. There is uncertainty regarding the extent to which pesticides contribute to pollinator declines.
As the demand for safer chemicals grows, the field of alternatives assessment is becoming increasingly important in guiding the transition towards safer, less toxic alternatives. A major limitation that can hinder efforts is the lack of consistent criteria for defining “safer" alternatives. This guidance outlines key considerations for the identification and selection of safer alternatives.
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Draft TG Metal Release 15Feb 2021 EC
The OECD has published the Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.