By Date


  • 8-September-2017

    English

    Participate in the survey: Guiding Principles for Chemical Accident Prevention, Preparedness and Response

    This short survey aims to gather feedback from a wide range of stakeholders on the OECD Guiding Principles for Chemical Accidents Prevention, Preparedness. The feedback received from this survey will help us making sure the new version is an improvement from the past and that it meets current needs of users.

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  • 11-July-2017

    English

    Guidance Document on the Reporting of Defined Approaches and Individual Information Sources to be Used within Integrated Approaches to Testing and Assessment (IATA) for Skin Sensitisation

    With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides guidance on the reporting of defined approaches to testing and assessment in the area of skin sensitisation using the adverse outcome pathway (AOP) as a conceptual framework. Annex 1 (page 25) outlines twelve illustrative case studies for skin sensitisation and Annex 2 (page 279) lists information sources used within the case studies.

  • 7-July-2017

    English

    Portal on Per and Poly Fluorinated Chemicals

    Per- and poly-fluorinated alkyl substances (PFASs) are substances that have many manufacturing and industrial applications because they impart useful properties (fire resistance and oil, stain, grease and water repellency). Some of the properties are associated with environmental and human health concerns. To support a global transition towards safer alternatives, this Portal facilitates the exchange of information.

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  • 4-July-2017

    English

    Section 4: Health Effects

    New deadlines for comments: Draft updated TG 492 on RhCE for eye hazard potential and draft updated performance standards for the validation of similar methods. The deadline for public comments of 3 October 2016.

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  • 28-June-2017

    English

    OECD biotechnology newsletter updates

    OECD major events and activities relating to biotechnologies: latest developments are updated biannually in this Newsletter.

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  • 20-June-2017

    English

    Draft Guidance and Review Documents/Monographs

    The Draft Revised Guidance Document 160 on the BCOP and ICE Test Methods: Collection of Tissues for Histological Evaluation and Collection of Data is open for public comments until 21 February 2017.

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  • 19-June-2017

    English

    Unique Identifier for Transgenic Plants

    The OECD developed the BioTrack Product Database which accommodates Unique Identifiers to each transgenic (or genetically engineered) plant that is approved for commercial use, including planting and food/feed use. These Unique Identifiers are intended to be used as "keys" to access information of each transgenic product in this database and to ensure the safety of modern biotechnology products

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  • 13-April-2017

    English

    Fundamental And Guiding Principles For (Q)SAR Analysis Of Chemical Carcinogens with Mechanistic Considerations

    In this document the importance of mechanistic consideration in quantitative structure-activity relationship ((Q)SAR) analysis, the critical role of mechanistic consideration in improving various (Q)SAR approaches and possible integrative approaches of combining chemoinformatics and bioinformatics are discussed, mainly using carcinogenicity as an illustrative toxicity endpoint. The principles and issues described in this document are general and may also be used for various types of chemical assessment. The intended target of readership is for global chemical hazard/risk assessors in regulatory agencies, industries, non-governmental organization and academia who require reliable and scientifically supportable (Q)SAR information and predictions in their assessments as well as for developers/researchers who endeavour to produce scientifically reliable (Q)SAR predictive models and tools.

  • 13-April-2017

    English

    Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment

    With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides a set of principles for reporting defined approaches to testing and assessment that can be used as one of the components within IATA. Templates are also provided to enable a structured approach to their documentation in order to facilitate their evaluation. A defined approach to testing and assessment consists of a fixed data interpretation procedure (DIP) applied to data generated with a defined set of information sources to derive a result that can either be used on its own, or together with other information sources within an IATA, to satisfy a specific regulatory need. Thus, a defined approach to testing and assessment can be used to support the hazard identification, hazard characterisation and/or safety assessment of chemicals. This guidance is intended to be used alongside similar guidance aimed at harmonising the reporting of other IATA components such as QSARs, grouping and read-across strategies, and non-guideline in vitro methods.

  • 13-April-2017

    English

    Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests

    Acute toxicity tests are an area of focus for developing alternative assays and approaches to address animal welfare concerns. In the context of this document, acute toxicity studies refer to studies involving a single exposure to a test chemical and include those assessing systemic toxicity as well as those assessing local irritation, corrosion or sensitization. One approach to minimizing the use of animals for acute toxicity testing is to consider waiving a study that may be required based on scientific criteria. Another approach to reducing or eliminating animal testing is to use existing hazard information that is informative for the acute toxicity endpoint for the test chemical; this would include the use of hazard information for one or multiple similar test chemicals to characterize the hazard for another or for mixtures, the use of recognized calculation approaches and bridging concepts. This Document provides clarification on these approaches to ensure that regulatory authorities are provided with the appropriate data required for decision-making and that reduced animal testing can be undertaken without compromising the integrity of the hazard information.

     

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