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Essais des produits chimiques

Webinar Series on Testing and Assessment Methodologies

 

The OECD webinars on Testing and Assessment Methodologies focus on selected ongoing projects that will result in the short to medium term in new methodologies to test and assess chemicals. These free webinars are open to potential end users among regulators and contract research organisations who want to get familiar with new standards and approaches. Video recordings of our webinars are made available online afterwards.

WEBINAR on the Implementation of the first stand-alone NAMs for eye hazard identification into OECD Guidelines: OECD GL 467 and TG 492B

Webinar on the implementation of the first stand-alone NAMs for eye hazard identification into OECD Guidelines: OECD GL 467 and TG 492B

WHEN: Tuesday 27 September 2022 at 14:00 - 15:30 (CEST) / 08:00 - 09:30 (EDT)

In the past decade, a number of Non-Animal Methods (NAMs) for predicting eye hazards of chemicals have been adopted as OECD Test Guidelines. However, to this date, no single NAM could completely replace the in vivo Draize eye test method due to the difficulty with predicting the middle category (i.e., eye irritation) for eye hazards. Studies have shown that this difficulty is linked to the eye irritation being caused by multiple drivers as well as the variability and inconsistency within the results from the Draize eye test, which is used as reference data for evaluating the predictive capacity of the NAMs for eye hazard identification. 

The newly adopted OECD GL 467 on Defined Approaches addresses this challenge and is the first stand-alone NAM based OECD Guideline. Defined approaches in OECD GL 467 use multiple information sources according to a fixed Data Interpretation Procedure (DIP) and allow for prediction of all eye hazard categories. The OECD also recently adopted TG 492B, another stand-alone NAM based OECD Guideline.

 

 

The OECD is organising this webinar to increase the awareness of these newly adopted guidelines for regulatory acceptance and to recognise the efforts of the organisation, as well as its stakeholders to commit to 3R principles for chemical hazard testing. 

 

This webinar will consist of three parts:

1) Draize eye test Reference Database (DRD)

2) OECD Guideline 467 on Defined Approaches for Serious Eye Damage and Eye Irritation

3) OECD Test Guideline 492B on Reconstructed Human Cornea-like Epithelium (RHCE) Test Method for Eye Hazard Identification.

 

REGISTER HERE

 

  

MISSED OUR previous WEBINARS? WATCH THE VIDEO RECORDINGS

Webinar on Physiologically Based Kinetic (PBK) Models

 

6 April 2022: Gaining acceptance in next generation PBK modelling approaches for regulatory assessments: case studies | Access the presentations here.

10 May 2021: Gaining acceptance in next generation PBK modelling approaches for regulatory assessment | Access the presentation here.

 

Webinars on Adverse Outcome Pathways (AOPs) 

25 January 2022: AOP co-operative activities between scientific journals and the OECD

  • The AOP framework: Dan Villeneuve | Presentation.
  • The importance of co-operation: Clemens Wittwehr (EC Joint Research Centre) | Presentation.
  • The OECD AOP review and endorsement process: Nathalie Delrue (OECD Secretariat) | Presentation.
  • Case study and Lessons learnt from ET&C and EMM: Dries Knapen (University of Antwerp, Belgium) and Jason O’Brien (National Wildlife Research Centre, Canada) | Presentation.

30 November 2020: Training needs, resources, and opportunities for Adverse Outcome Pathways (AOPs) | Presentations:

  • Introduction by Magdalini Sachana and Mirjam Luijten | Presentation
  • From Data to Knowledge and Beyond AOPs as common interface by Brigitte Landesmann | Presentation
  • OECD Programme on Adverse Outcome Pathways (AOPs) by Bette Meek | Presentation
  • Concluding remarks by Mirjam Luijten | Presentation

30 January 2020: AOP knowledge base and AOP developing tips | Presentations:

  • Nathalie Delrue from the OECD Environment Directorate introduced the presenters and scope of the webinar | Presentation
  • Clemens Wittwehr from the European Commission Joint Research Centre provided an introduction on AOP-KB | Presentation
  • Dan Villeneuve from the US Environmental Protection Agency provided some tips on the development of AOPs | Presentation
  • Holly Mortensen from the US Environmental Protection Agency presented ways of retrieving information from databases and other AOP tools | Presentation

15 January 2020: Assembling and evaluating weight of evidence and quantitative understanding | Presentations

  • Magda Sachana from the OECD Environment Directorate introduced the presenters and scope of the webinar | Presentation
  • Bette Meek from the University of Ottawa provided an introduction to WoE for AOPs | Presentation
  • Kristie Sullivan from the Physicians Committee for Responsible Medicine shared examples of implementing WoE in an AOP | Presentation
  • Dan Villeneuve from the US Environmental Protection Agency spoke about quantitative understanding of relationships and why that’s important | Presentation.

30 April 2019: Adverse Outcome Pathway (AOP) framework | Presentations: 

  • Nathalie Delrue (OECD Secretariat): OECD AOP Programme | Presentation
  • Catherine Willett (Humane Society International): An Introduction to AOP framework | Presentation
  • Jason O’Brien (Environment Canada): AOP collaborative development | Presentation
  • Dan Villeneuve (US Environmental Protection Agency): Examples of AOP application in chemical risk assessment | Presentation 

 

Webinars on Testing and Assessment Methodologies:

18 October 2021: Implementation of the Defined Approaches on Skin Sensitisation for Chemical Safety

  • Anne Gourmelon: OECD Environment Directorate | Presentation
  • Nicole Kleinestreuer (NICEATM) and Silvia Casati (EURL ECVAM) | Presentation
  • Anna Lowit (US EPA OPP)
  • Paul Brown (US FDA) 
  • Laura Rossi (ECHA) | Presentation
  • Andre Muller (RIVM) | Presentation

Access the Question and Answers document here

27 September 2019: OECD Alternatives to in vivo eye irritation testing

  • Chantra Eskes (Swiss 3Rs Competence Centre): Available test methods and IATA Guidance Document 263 | Presentation
  • Dave Allen (Integrated Laboratory Systems): Alternatives for eye irritation testing: usefulness and limitations | Presentation
  • Bertrand Desprez (Cosmetics Europe): Two defined approaches for ocular toxicity predictions | Presentation

16 January 2019: Defined Approaches for Skin Sensitisation

 

Webinars on Nanomaterials:

2 December 2021: How to assess exposure to nanomaterials? The evaluation results of existing tools/models (English - Spanish)

  • Occupational project: Carla Ribalta Carrasco, PhD (Danish National Research Center for Working Environment) | Occupational project
  • Consumer project: Mohammad Zein Aghaji, PhD (Health Canada) | Presentation
  • Environmental project: Marc LaPointe, Mathieu Dextraze (Environment and Climate Change Canada) | Presentation

25 February 2021: Assessing the dispersion stability and dissolution rate of nanomaterials in the environment

The recording is available in Spanish / El video está disponible en español.

26 January 2021: Guidance document No. 317 on aquatic & sediment ecotoxicity testing of nanomaterials

The recording is available in Spanish / El video está disponible en español.

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