Testing of chemicals

Webinar Series on Testing and Assessment Methodologies


The OECD webinars on Testing and Assessment Methodologies focus on selected ongoing projects that will result in the short to medium term in new methodologies to test and assess chemicals. These free webinars are open to potential end users among regulators and contract research organisations who want to get familiar with new standards and approaches. Video recordings of our webinars are made available online afterwards.

REGISTER FOR OUR UPCOMING WEBINAR on the implementation of the defined approaches on skin sensitisation 

Webinar Implementation of the Defined Approaches on Skin Sensitisation (OECD GL 497) for chemical safety in member countries

WHEN: 18 October 2021 @ 14:00 CEST (Paris time) / 08:00 EDT

‌Humans and the environment are exposed every day to chemicals. How do we make sure that these chemicals are safe?

Industry is required to test these chemicals to understand how they may affect people and the environment. In the past, these tests were most commonly carried out on animals. As scientific methods and tools progress, the use of animals to test a product designed for humans are becoming obsolete, in addition to being unethical. With new methods being developed, it is possible to perform these tests on human and animal cell cultures with equally rigorous and robust results. Because the OECD is committed to chemical safety and animal welfare, a new ground-breaking Guideline on Defined Approaches for Skin Sensitisation (OECD GL 497) was released on 14 June 2021. It is the first ever Guideline that uses non-animal methods to predict whether a chemical can cause skin allergies.

The OECD will organise a webinar on 18 October 2021 at 14:00 to discuss the implementation of the Defined Approaches on Skin Sensitisation for chemical safety in member countries. This webinar will pave the way for companies and authorities to determine the environmental toxicity of chemicals without having to resort to animal testing.


  • Nicole Kleinestreuer: NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)
  • Silvia Casati:  European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM)
  • Anna Lowit: U.S. Environmental Protection's Office of Pesticide Programs  (US EPA OPP)
  • Paul Brown: U.S. Food and Drug Administration (US FDA)
  • Laura Rossi: European Chemicals Agency (ECHA)
  • Andre Muller: National Institute for Public Health and the Environment (RIVM)



Missed our webinar on gaining acceptance in next generation pbk modelling approaches for regulatory approaches? Watch the video recording

On 10 May 2021, the OECD presented the recently published Guidance Document on the Characterisation, Validation and Reporting of Physiologically Based Kinetic (PBK) Models for Regulatory Purposes. This guidance aims to increase the confidence in the use of PBK models parameterised with data derived from in vitro and in silico methods, and help address “unfamiliar” uncertainties associated with these methods.

The webinar introduced the assessment framework for PBK models that was developed to evaluate the attributes and uncertainties of these models, including a dedicated discussion on sensitivity analysis. It also focused on the scientific workflow for characterising and validating PBK models together with a template for documenting PBK models in a systematic manner and a checklist to support model evaluation.

Access the presentation here.



Webinars on Adverse Outcome Pathways (AOPs) 

30 November 2020: Training needs, resources, and opportunities for Adverse Outcome Pathways (AOPs) | Presentations:

  • Introduction by Magdalini Sachana and Mirjam Luijten | Presentation
  • From Data to Knowledge and Beyond AOPs as common interface by Brigitte Landesmann | Presentation
  • OECD Programme on Adverse Outcome Pathways (AOPs) by Bette Meek | Presentation
  • Concluding remarks by Mirjam Luijten | Presentation

30 January 2020: AOP knowledge base and AOP developing tips | Presentations:

      • Nathalie Delrue from the OECD Environment Directorate introduced the presenters and scope of the webinar | Presentation
      • Clemens Wittwehr from the European Commission Joint Research Centre provided an introduction on AOP-KB | Presentation
      • Dan Villeneuve from the US Environmental Protection Agency provided some tips on the development of AOPs | Presentation
      • Holly Mortensen from the US Environmental Protection Agency presented ways of retrieving information from databases and other AOP tools | Presentation

15 January 2020: Assembling and evaluating weight of evidence and quantitative understanding | Presentations

      • Magda Sachana from the OECD Environment Directorate introduced the presenters and scope of the webinar | Presentation
      • Bette Meek from the University of Ottawa provided an introduction to WoE for AOPs | Presentation
      • Kristie Sullivan from the Physicians Committee for Responsible Medicine shared examples of implementing WoE in an AOP | Presentation
      • Dan Villeneuve from the US Environmental Protection Agency spoke about quantitative understanding of relationships and why that’s important | Presentation.

30 April 2019: Adverse Outcome Pathway (AOP) framework | Presentations: 

      • Nathalie Delrue (OECD Secretariat): OECD AOP Programme | Presentation
      • Catherine Willett (Humane Society International): An Introduction to AOP framework | Presentation
      • Jason O’Brien (Environment Canada): AOP collaborative development | Presentation
      • Dan Villeneuve (US Environmental Protection Agency): Examples of AOP application in chemical risk assessment | Presentation 


Webinars on Testing and Assessment Methodologies:

27 September 2019: OECD Alternatives to in vivo eye irritation testing

      • Chantra Eskes (Swiss 3Rs Competence Centre): Available test methods and IATA Guidance Document 263 | Presentation
      • Dave Allen (Integrated Laboratory Systems): Alternatives for eye irritation testing: usefulness and limitations | Presentation
      • Bertrand Desprez (Cosmetics Europe): Two defined approaches for ocular toxicity predictions | Presentation

16 January 2019: Defined Approaches for Skin Sensitisation


Webinars on Nanomaterials:

25 February 2021: Assessing the dispersion stability and dissolution rate of nanomaterials in the environment

The recording is available in Spanish / El video está disponible en español.

26 January 2021: Guidance document No. 317 on aquatic & sediment ecotoxicity testing of nanomaterials

The recording is available in Spanish / El video está disponible en español.



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