Testing of chemicals

Webinar Series on Testing and Assessment Methodologies


The OECD webinars on Testing and Assessment Methodologies focus on selected ongoing projects that will result in the short to medium term in new methodologies to test and assess chemicals. These free webinars are open to potential end users among regulators and contract research organisations who want to get familiar with new standards and approaches. Video recordings of our webinars are made available online afterwards.

register for our upcoming webinar: gaining acceptance in next generation pbk modelling approaches for regulatory approaches

The fields of toxicology and chemical risk assessment evaluate the safety of chemicals for humans the environment. Increasingly, modern methods seek to reduce the use of animals in chemical safety testing and predictive toxicology.WHEN: 10 May 2021 @ 13:20 - 15:30 (CEST) / 07:20 - 09:30 (EDT)

The OECD Hazard Assessment Programme is increasingly exploring the use of alternative (non-animal) methods to aid the chemical risk assessment process. Recently, the OECD published a Guidance Document on the Characterisation, Validation and Reporting of Physiologically Based Kinetic (PBK) Models for Regulatory Purposes. This guidance aims to increase the confidence in the use of PBK models parameterised with data derived from in vitro and in silico methods, and help address “unfamiliar” uncertainties associated with these methods.

Join us to hear about the assessment framework for PBK models that was developed to evaluate the attributes and uncertainties of these models, including a dedicated discussion on sensitivity analysis. This webinar will present the scientific workflow for characterising and validating PBK models together with a template for documenting PBK models in a systematic manner and a checklist to support model evaluation.

If you are from the community of PBK model developers, or the proponent of a model in a regulatory submission, or a regulator who needs to assess the applicability of the models in chemical evaluations, this webinar is for you!    


    • Magda Sachana (OECD Environment Directorate): Welcome & goals of webinar
    • Cecilia Tan (US Environmental Protection Agency): 1) Introduction to GD needs and goals difference with other GD and 2) Reporting template and checklist
    • Iain Gardner (Certara): Parametrisation in vitro in silico
    • Marina Evans (US Environmental Protection Agency): Sensitivity Analysis –Theory
    • George Loizou (UK Health and Safety Laboratory): Global Sensitivity Analysis –examples
    • Alicia Paini (JRC, Ispra): 1) Decision tree for data poor chemical – Read across approach and 2) Case Studies examples
    • Andrew Worth (JRC, Ispra): Evaluation Framework



watch the video recordings of past webinars on nanomaterials 

The recording is available in Spanish / El video está disponible en español

On Thursday 25 February 2021, Anne Gourmelon (Environment Directorate, OECD), Kathrin Schwirn (German Environment Agency, Umweltbundesamt, UBA); Frank von der Kammer (University of Vienna) Research and Development Center) and Doris Völker (German Environment Agency, Umweltbundesamt, UBA) presented the scope, content, and use of the Test Guideline No. 318: Dispersion Stability of Nanomaterials in Simulated Environmental Media and its accompanying Guidance Document. Further discussions focused on the scope of the upcoming Test Guideline.


The recording is available in Spanish / El video está disponible en español

On Tuesday 26 January 2021, Anne Gourmelon (Environment Directorate, OECD), Elijah J. Petersen (National Institute of Standards and Technology); Alan Kennedy (Engineering Research and Development Center) and Gregory Goss (University of Alberta) presented the scope and use of the guidance document No. 317 on aquatic and sediment ecotoxicity testing of nanomaterials. The guidance addresses practical aspects of carrying out valid tests on nanomaterials, and modifications or additions to OECD Test Guidelines procedures intended to improve the accuracy of test results.




Webinars on Adverse Outcome Pathways (AOPs) 

30 November 2020: Training needs, resources, and opportunities for Adverse Outcome Pathways (AOPs) | Presentations:

  • Introduction by Magdalini Sachana and Mirjam Luijten | Presentation
  • From Data to Knowledge and Beyond AOPs as common interface by Brigitte Landesmann | Presentation
  • OECD Programme on Adverse Outcome Pathways (AOPs) by Bette Meek | Presentation
  • Concluding remarks by Mirjam Luijten | Presentation

30 January 2020: AOP knowledge base and AOP developing tips | Presentations:

      • Nathalie Delrue from the OECD Environment Directorate introduced the presenters and scope of the webinar | Presentation
      • Clemens Wittwehr from the European Commission Joint Research Centre provided an introduction on AOP-KB | Presentation
      • Dan Villeneuve from the US Environmental Protection Agency provided some tips on the development of AOPs | Presentation
      • Holly Mortensen from the US Environmental Protection Agency presented ways of retrieving information from databases and other AOP tools | Presentation

15 January 2020: Assembling and evaluating weight of evidence and quantitative understanding | Presentations

      • Magda Sachana from the OECD Environment Directorate introduced the presenters and scope of the webinar | Presentation
      • Bette Meek from the University of Ottawa provided an introduction to WoE for AOPs | Presentation
      • Kristie Sullivan from the Physicians Committee for Responsible Medicine shared examples of implementing WoE in an AOP | Presentation
      • Dan Villeneuve from the US Environmental Protection Agency spoke about quantitative understanding of relationships and why that’s important | Presentation.

30 April 2019: Adverse Outcome Pathway (AOP) framework | Presentations: 

      • Nathalie Delrue (OECD Secretariat): OECD AOP Programme | Presentation
      • Catherine Willett (Humane Society International): An Introduction to AOP framework | Presentation
      • Jason O’Brien (Environment Canada): AOP collaborative development | Presentation
      • Dan Villeneuve (US Environmental Protection Agency): Examples of AOP application in chemical risk assessment | Presentation 


Webinars on Testing and Assessment Methodologies:

27 September 2019: OECD Alternatives to in vivo eye irritation testing

      • Chantra Eskes (Swiss 3Rs Competence Centre): Available test methods and IATA Guidance Document 263 | Presentation
      • Dave Allen (Integrated Laboratory Systems): Alternatives for eye irritation testing: usefulness and limitations | Presentation
      • Bertrand Desprez (Cosmetics Europe): Two defined approaches for ocular toxicity predictions | Presentation

16 January 2019: Defined Approaches for Skin Sensitisation




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