The OECD webinars on Testing and Assessment Methodologies focus on selected ongoing projects that will result in the short to medium term in new methodologies to test and assess chemicals. These free webinars are open to potential end users among regulators and contract research organisations who want to get familiar with new standards and approaches. Video recordings of our webinars are made available online afterwards.
WEBINAR REPLAY ON Gaining acceptance in next generation PBK modelling approaches for regulatory assessments: Case studies
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On 6 April 2022, the OECD organised a second webinar on the application of the assessment framework for Physiologically Based Kinetic (PBK) models. The webinar presented two case studies and illustrated how the templates of the guidance were used to report and evaluate PBK models. A discussion took place on challenges related to the regulatory evaluation of PBK models and clarifications on aims and scope of these models were provided. The OECD is increasingly exploring the use of alternative (non-animal) methods to aid the chemical risk assessment process. In 2021, the OECD published a Guidance Document on the Characterisation, Validation and Reporting of Physiologically Based Kinetic (PBK) Models For Regulatory Purposes that aims to increase the confidence in the use of PBK models parameterised with data derived from in vitro and in silico methods, and help address “unfamiliar” uncertainties associated with these methods. Shortly after, the OECD organised an introductory webinar on “Gaining acceptance in next generation PBK modelling approaches for regulatory assessments”. This first webinar covered the assessment framework for PBK models that was developed to evaluate the attributes and uncertainties of these models and included discussions on sensitivity analysis. Watch the video replay and access the presentations. |
Programme and speakers:
Access the presentations here.
WATCH THE WEBINAR REPLAY on adverse outcome pathway (AOP) co-operative activities between scientific journals and the oecd
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On 25 January 2022, the OECD held a webinar on Adverse Outcome Pathway (AOP) co-operative activities between Scientific journals and the OECD. This webinar was organised primarily for Scientific Journal editors or publishers who are interested in reviewing/publishing AOPs and collaborating with the OECD in this activity. The main objectives and advantages of such cooperation are to:
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Two scientific journals, ‘Environmental Toxicology and Chemistry (ET&C)’ and ‘Environmental and Molecular Mutagenesis (EMM)’ have been pioneers in this approach and have worked with the OECD to develop an agreement between the Journal and the OECD where the scientific review is conducted in line with the OECD quality standards described in the Guidance Document for the scientific review of AOPs. The first two AOPs that followed that path were accepted by ET&C recently and the corresponding Journal Format Articles are published in a Virtual issue of ET&C called ‘AOP Pathways & Predictions’.
The objective of the webinar was to present the basis for cooperation between scientific journals and the OECD and discuss the lessons learnt so far. The following presentations were followed by a Q&A session.
MISSED OUR previous WEBINARS? WATCH THE VIDEO RECORDINGS
Webinar on Physiologically Based Kinetic (PBK) Models
10 May 2021: Gaining acceptance in next generation PBK modelling approaches for regulatory assessment
The OECD presented the recently published Guidance Document on the Characterisation, Validation and Reporting of Physiologically Based Kinetic (PBK) Models for Regulatory Purposes. This guidance aims to increase the confidence in the use of PBK models parameterised with data derived from in vitro and in silico methods, and help address “unfamiliar” uncertainties associated with these methods.
The webinar introduced the assessment framework for PBK models that was developed to evaluate the attributes and uncertainties of these models, including a dedicated discussion on sensitivity analysis. It also focused on the scientific workflow for characterising and validating PBK models together with a template for documenting PBK models in a systematic manner and a checklist to support model evaluation. Access the presentation here.
Webinars on Adverse Outcome Pathways (AOPs)
30 November 2020: Training needs, resources, and opportunities for Adverse Outcome Pathways (AOPs) | Presentations:
30 January 2020: AOP knowledge base and AOP developing tips | Presentations:
15 January 2020: Assembling and evaluating weight of evidence and quantitative understanding | Presentations
30 April 2019: Adverse Outcome Pathway (AOP) framework | Presentations:
Webinars on Testing and Assessment Methodologies:
18 October 2021: Implementation of the Defined Approaches on Skin Sensitisation for Chemical Safety
Access the Question and Answers document here.
27 September 2019: OECD Alternatives to in vivo eye irritation testing
16 January 2019: Defined Approaches for Skin Sensitisation
Webinars on Nanomaterials:
2 December 2021: How to assess exposure to nanomaterials? The evaluation results of existing tools/models (English - Spanish)
The recording is available in Spanish / El video está disponible en español.
The recording is available in Spanish / El video está disponible en español.
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