Peer review package of the Test Guideline 442C on Amino acid Derivative Reactivity Assay (ADRA):

 

• Document No. 1:  Draft proposal for the update of appendix II of Test Guideline No. 442C based on the project proposal 4.141 of the Test Guidelines programme workplan
• Document No. 2: Amino acid Derivative Reactivity Assay (ADRA) Using a Chemical Solution Prepared at 4 mM; ADRA (4 mM) JaCVAM Ring Study Report
• Document No. 3: Improving predictive capacity of the Amino acid Derivative Reactivity Assay test method for skin sensitization potential with an optimal molar concentration of test chemical solution
• Document No. 4: Within- and between-laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay (ADRA) using a 0.5 mg/ml test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories
• Document No. 5: Expanding the applicability of the amino acid derivative reactivity assay: Determining a weight for preparation of test chemical solutions that yield a predictive capacity identical to the conventional method using molar concentration and demonstrating the capacity to detect sensitizers in liquid mixtures
• Document No. 6: The amino acid derivative reactivity assay with fluorescence detection and its application to multi-constituent substances
• Document No. 7: A newly developed means of HPLC-fluorescence analysis for predicting the skin sensitization potential of multi-constituent substances using ADRA
• Document No. 8: Review of additional data generated with the Amino acid Depletion Reactivity Assay (ADRA)

 

Peer review package of the Test Guideline 442E on Interleukin-8 Reporter Gene Assay (IL-8 Luc assay):

 

• Document 1: Analysis aiming at revising the prediction model of IL‑8 Luc assay
• Document 2: Draft proposal for the update of Annex III of Test Guideline No. 442E based on the project proposal 4.148 of the Test Guidelines programme workplan
• Document 3: Draft revised SOP

 

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