Chemical safety and biosafety

Webinar Series on Testing and Assessment Methodologies


The OECD webinars on Testing and Assessment Methodologies focus on selected ongoing projects that will result in the short to medium term in new methodologies to test and assess chemicals. These free webinars are open to potential end users among regulators and contract research organisations who want to get familiar with new standards and approaches. Video recordings of our webinars are made available online afterwards.

JOIN THE WEBINAR on adverse outcome pathway (AOP) co-operative activities between scientific journals and the oecd

Webinar on Adverse Outcome Pathway (AOP) co-operative activities between scientific journals and the OECD

The OECD is organising a webinar on Adverse Outcome Pathway (AOP) co-operative activities between Scientific journals and the OECD on Tuesday 25 January 2022 from 13:00-14:30 CET / 7:00-8:30 EST.

This webinar is organised primarily for Scientific Journal editors or publishers who are interested in reviewing/publishing AOPs and collaborating with the OECD in this activity.

The main objectives and advantages of such cooperation are to:

  • Increase the rate of AOP scientific reviews by distributing the burden of organising and managing those reviews across a broader range of organisations;
  • Incentivise more AOP contributions by providing authors with the career recognition associated with a peer-reviewed publication; and
  • Benefit participating journals by providing “review-like” articles with high citation potential.

Two scientific journals, ‘Environmental Toxicology and Chemistry (ET&C)’ and ‘Environmental and Molecular Mutagenesis (EMM)’ have been pioneers in this approach and have worked with the OECD to develop an agreement between the Journal and the OECD where the scientific review is conducted in line with the OECD quality standards described in the Guidance Document for the scientific review of AOPs. The first two AOPs that followed that path were accepted by ET&C recently and the corresponding Journal Format Articles are published in a Virtual issue of ET&C called ‘AOP Pathways & Predictions’.

The objective of the webinar will be to present the basis for cooperation between scientific journals and the OECD and discuss the lessons learnt so far. The following presentations will be followed by a Q&A session.

  • The AOP framework: Dan Villeneuve (US EPA) will present the AOP framework and challenges being encountered.
  • The importance of co-operation: Based on the outcome of a workshop recently held on ‘Science with impact in an era of information overload’, Clemens Wittwehr (EC Joint Research Centre) will focus on the importance of an increased cooperation between all stakeholders in order to promote the application of the AOP framework.
  • The OECD AOP review and endorsement process: Nathalie Delrue (OECD Secretariat) will present the OECD AOP review principles and endorsement process and will describe how the cooperation between OECD and scientific journals is formalised in the terms of a Memorandum of Understanding. 
  • Case study and Lessons learnt from ET&C and EMM: Dries Knapen (University of Antwerp, Belgium) and Jason O’Brien (National Wildlife Research Centre, Canada) will present lessons learnt from the pilot study conducted at Environmental Toxicology and Chemistry (ET&C) and at Environmental and Molecular Mutagenesis (EMM), with the first AOPs and how the journal review process was optimised in this context.




Webinar on Physiologically Based Kinetic (PBK) Models

10 May 2021: Gaining acceptance in next generation PBK modelling approaches for regulatory assessment

The OECD presented the recently published Guidance Document on the Characterisation, Validation and Reporting of Physiologically Based Kinetic (PBK) Models for Regulatory Purposes. This guidance aims to increase the confidence in the use of PBK models parameterised with data derived from in vitro and in silico methods, and help address “unfamiliar” uncertainties associated with these methods.

The webinar introduced the assessment framework for PBK models that was developed to evaluate the attributes and uncertainties of these models, including a dedicated discussion on sensitivity analysis. It also focused on the scientific workflow for characterising and validating PBK models together with a template for documenting PBK models in a systematic manner and a checklist to support model evaluation. Access the presentation here.


Webinars on Adverse Outcome Pathways (AOPs) 

30 November 2020: Training needs, resources, and opportunities for Adverse Outcome Pathways (AOPs) | Presentations:

  • Introduction by Magdalini Sachana and Mirjam Luijten | Presentation
  • From Data to Knowledge and Beyond AOPs as common interface by Brigitte Landesmann | Presentation
  • OECD Programme on Adverse Outcome Pathways (AOPs) by Bette Meek | Presentation
  • Concluding remarks by Mirjam Luijten | Presentation

30 January 2020: AOP knowledge base and AOP developing tips | Presentations:

  • Nathalie Delrue from the OECD Environment Directorate introduced the presenters and scope of the webinar | Presentation
  • Clemens Wittwehr from the European Commission Joint Research Centre provided an introduction on AOP-KB | Presentation
  • Dan Villeneuve from the US Environmental Protection Agency provided some tips on the development of AOPs | Presentation
  • Holly Mortensen from the US Environmental Protection Agency presented ways of retrieving information from databases and other AOP tools | Presentation

15 January 2020: Assembling and evaluating weight of evidence and quantitative understanding | Presentations

  • Magda Sachana from the OECD Environment Directorate introduced the presenters and scope of the webinar | Presentation
  • Bette Meek from the University of Ottawa provided an introduction to WoE for AOPs | Presentation
  • Kristie Sullivan from the Physicians Committee for Responsible Medicine shared examples of implementing WoE in an AOP | Presentation
  • Dan Villeneuve from the US Environmental Protection Agency spoke about quantitative understanding of relationships and why that’s important | Presentation.

30 April 2019: Adverse Outcome Pathway (AOP) framework | Presentations: 

  • Nathalie Delrue (OECD Secretariat): OECD AOP Programme | Presentation
  • Catherine Willett (Humane Society International): An Introduction to AOP framework | Presentation
  • Jason O’Brien (Environment Canada): AOP collaborative development | Presentation
  • Dan Villeneuve (US Environmental Protection Agency): Examples of AOP application in chemical risk assessment | Presentation 


Webinars on Testing and Assessment Methodologies:

18 October 2021: Implementation of the Defined Approaches on Skin Sensitisation for Chemical Safety

  • Anne Gourmelon: OECD Environment Directorate | Presentation
  • Nicole Kleinestreuer (NICEATM) and Silvia Casati (EURL ECVAM) | Presentation
  • Anna Lowit (US EPA OPP)
  • Paul Brown (US FDA) 
  • Laura Rossi (ECHA) | Presentation
  • Andre Muller (RIVM) | Presentation

Access the Question and Answers document here

27 September 2019: OECD Alternatives to in vivo eye irritation testing

  • Chantra Eskes (Swiss 3Rs Competence Centre): Available test methods and IATA Guidance Document 263 | Presentation
  • Dave Allen (Integrated Laboratory Systems): Alternatives for eye irritation testing: usefulness and limitations | Presentation
  • Bertrand Desprez (Cosmetics Europe): Two defined approaches for ocular toxicity predictions | Presentation

16 January 2019: Defined Approaches for Skin Sensitisation


Webinars on Nanomaterials:

2 December 2021: How to assess exposure to nanomaterials? The evaluation results of existing tools/models (English - Spanish)

  • Occupational project: Carla Ribalta Carrasco, PhD (Danish National Research Center for Working Environment) | Occupational project
  • Consumer project: Mohammad Zein Aghaji, PhD (Health Canada) | Presentation
  • Environmental project: Marc LaPointe, Mathieu Dextraze (Environment and Climate Change Canada) | Presentation


25 February 2021: Assessing the dispersion stability and dissolution rate of nanomaterials in the environment

The recording is available in Spanish / El video está disponible en español.

26 January 2021: Guidance document No. 317 on aquatic & sediment ecotoxicity testing of nanomaterials

The recording is available in Spanish / El video está disponible en español.



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