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  • 18-October-2021

    English

    Webinar Series on Testing and Assessment Methodologies

    Join us on 18 October 2021 at 14:00 to discuss the implementation of the Defined Approaches on Skin Sensitisation for chemical safety in member countries. This webinar will pave the way for companies and authorities to determine the environmental toxicity of chemicals without having to resort to animal testing.

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  • 14-October-2021

    English

    Draft Guidance and Review Documents/Monographs

    Interested parties are invited to send their comments on the Draft Guidance Document for the Scientific Review of Adverse Outcome Pathways by 18 June 2021.

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  • 21-September-2021

    English

    Good Laboratory Practice (GLP)

    Read the countries' response to address the challenges posed by COVID-19 to GLP test facilities.

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  • 21-September-2021

    English

    OECD Series on Principles of Good Laboratory Practice (GLP) and Compliance Monitoring

    This OECD Advisory Document on Good Laboratory Practice (GLP) Data Integrity provides guidance for test facilities or test sites that conduct GLP studies and aims to promote a risk-based approach to the management of data.

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  • 13-September-2021

    English

    Section 4: Health Effects

    Interested parties are invited to send their comments on the draft OECD Guideline on Defined Approaches for Serious Eye Damage/Eye Irritation, Supporting Document for Evaluation and Review of Draft Guideline (GL) For Defined Approaches (DAs) for Serious Eye Damage / Eye Irritation and TG 492B on Reconstructed Human Cornea-like Epithelium (RHCE) test method for eye hazard identification. Comments should be sent by 13 September 2021.

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  • 27-August-2021

    English

    Series on Testing and Assessment: publications by number

    This Series includes publications related to testing and assessment of chemicals; some of them support the development of OECD Test Guidelines (e.g. validation reports, guidance documents, detailed review papers).

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  • 28-July-2021

    English

    Intellectual Property elements in OECD Test Guidelines

    With the development of new technologies, new ways of testing chemicals have emerged and will increasingly develop given the trend to move away from animal testing. These new methods generally include Intellectual Property Rights. To date, many Test Guidelines for in vitro methods already include proprietary elements.

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  • 28-July-2021

    English

    OECD Work Related to Bees/Pollinators

    There have been reports these last years of declines in native and managed pollinators in several regions of the world. Potential factors associated with these declines are hypothesised to include habitat destruction, predators, certain agricultural practices, bee management practices, pathogens, climate change, nutrition and pesticides. There is uncertainty regarding the extent to which pesticides contribute to pollinator declines.

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  • 17-June-2021

    English

    Test No. 405: Acute Eye Irritation/Corrosion

    This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is applied in a single dose in the conjunctival sac of one eye of each animal. The other eye, which remains untreated, serves as a control. The initial test uses an animal; the dose level depends on the test substance nature. A confirmatory test should be made if a corrosive effect is not observed in the initial test, the irritant or negative response should be confirmed using up to two additional animals. It is recommended that it be conducted in a sequential manner in one animal at a time, rather than exposing the two additional animals simultaneously. The duration of the observation period should be sufficient to evaluate fully the magnitude and reversibility of the effects observed. The eyes should be examined at 1, 24, 48, and 72 hours after test substance application. The ocular irritation scores should be evaluated in conjunction with the nature and severity of lesions, and their reversibility or lack of reversibility. Use of topical anesthetics and systemic analgesics to avoid or minimize pain and distress in ocular safety testing procedures is described.
  • 2-March-2021

    English

    Substitution of hazardous chemicals

    As the demand for safer chemicals grows, the field of alternatives assessment is becoming increasingly important in guiding the transition towards safer, less toxic alternatives. A major limitation that can hinder efforts is the lack of consistent criteria for defining “safer" alternatives. This guidance outlines key considerations for the identification and selection of safer alternatives.

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