The OECD Environmental, Health and Safety (EHS) Programme has been helping member countries to make better use of increased knowledge of how chemicals induce adverse effects in humans and wildlife, through the so-called Adverse Outcome Pathways.
Four new AOPs were recently published in iLibrary, following scientific review and OECD endorsement:
Published on 23 October 2023:
No. 32: Adverse Outcome Pathway on deposition of energy leading to lung cancer | Authors: Samantha Sherman, Zakara Said, Baki Sadi, Carole Yauk, Danielle Beaton, Ruth Wilkins, Robert Stainforth, Nadine Adam and Vinita Chauhan
No. 31: Disruption of VEGFR signaling leading to developmental defects | Authors: Thomas B. Knudsen, Katerine Saili, Jill Franzosa, Nancy Baker, Richard Spencer, Tamara Tal, Nicole Kleinstreuer, Tuula Heinonen, Rob Ellis-Hutchings, Neil Vargesson and Maria Bondesson
No. 30: Adverse Outcome Pathway on impaired interleukin-1 receptor type I (IL-1R1) signaling leading to impaired T-cell dependent antibody response | Authors: Yutaka Kimura, Setsuya Aiba, Takao Ashikaga, Takumi Ohishi and Kiyoshi Kushima
Published on 11 July 2023:
No. 29: Oxidative DNA damage leading to chromosomal aberrations and mutations | Authors: Eunnara Cho, Ashley Allemang, Marc Audebert, Vinita Chauhan, Stephen Dertinger, Giel Hendriks, Mirjam Luijten, Francesco Marchetti, Sheroy Minocherhomji, Stefan Pfuhler, Daniel J. Roberts, Kristina Trenz, Carole L. Yauk
The OECD launched a new programme on the development of Adverse Outcome Pathways (AOP) in 2012. An AOP is an analytical construct that describes a sequential chain of causally linked events at different levels of biological organisation that lead to an adverse health or ecotoxicological effect (see figure below). AOPs are the central element of a toxicological knowledge framework being built to support chemical risk assessment based on mechanistic reasoning.
Schematic representation of the AOP illustrated with reference to a number of pathways
Watch our video: OECD work on Adverse Outcome Pathway
Access all publications on Adverse Outcome Pathways. Find the OECD Series on Adverse Outcome Pathways on iLibrary .
The Advisory Group on Emerging Science in Chemicals Assessment (ESCA) oversees the essential elements of the AOP Programme. This group works towards the development of AOPs with the support of and in close collaboration with the AOP-KB Coordination Group and of the Society for the Advancement of AOPs (SAAOP). The latter serves as the primary interface between the OECD ESCA and the broader AOP community of practice.
Representation of the AOP Development Process at the OECD
The OECD is developing co-operation with Scientific Journals for the review and publication of AOPs.
This cooperation is formalised in the signature of a Memorandum of understanding (MOU). Scientific Journal Signatories take part in the scientific review of AOPs relevant to their field of expertise, with the view to achieve the following common objectives:
The conditions of the MOU are summarised here.
The following Journals have already signed an MOU with the OECD:
The OECD's AOP Knowledge Base tools, constantly developed and refined, are a web-based platform which aims to bring together all knowledge on how chemicals can induce adverse effects, therefore providing a focal point for AOP development and dissemination.
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The OECD Test Guidelines Programme for the identification of new biomaker endpoints and in vitro test methods that are candidates to become part of OECD Test Guidelines.
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