Increasing incidents of disorders such as obesity/diabetes/metabolic syndrome, reproductive
dysfunction, and neuro-developmental abnormalities in some human populations have
raised concern that disruption of key endocrine-signaling pathways by exposure to
environmental chemicals may be involved. This Detailed Review Paper describes some
endocrine pathways that have been shown to be susceptible to environmental endocrine
disruption and whose disruption could contribute to increasing incidents of some disorders
in humans and wildlife populations.