Automation, digitalisation and technological change are profoundly affecting local labour markets in Canada as elsewhere across the OECD. Automation offers the opportunity to boost productivity, increasing prosperity and raising living standards. It can however also create losers, as workers who lose jobs to automation may not always have the skills needed in a changing labour market and might struggle to find new jobs. Places more vulnerable to automation than others tend to have some characteristics in common. Within Ontario, Canada’s most populous province and the driver of the Canadian economy, regions facing a higher risk of automation have larger employment shares in goods-producing sectors, a prevalence of rural communities and an older labour force. This study sheds light on main lessons and policy principles to prepare people, places and firms for the future of work in Canada. This report comes at a time when policy makers, citizens and businesses are challenged by the COVID-19 crisis that will generate a profound reflection on our production and consumption habits, as well as on local economy recovery policies. The COVID-19 crisis might also contribute to making the case for further automation in the workplace, as employers adopt new technology to increase productivity.