By Date


  • 3-September-2014

    English

    Fish Toxicity Testing Framework

    This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant. A review of regulatory needs for fish tests under various jurisdictions in OECD countries is provided in Chapter 2, followed by a review of statistical issues and general test considerations in Chapters 3 and 4, respectively. The

  • 3-September-2014

    English

    Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors

    This document describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption and whose disruption could contribute to increasing incidents of some disorders in humans and wildlife populations, such as obesity/diabetes/metabolic syndrome, reproductive dysfunction, and neuro-developmental abnormalities. Assays and endpoints are described that could be used in new or existing OECD Test

  • 3-September-2014

    English

    The Guidance Document for Using the OECD (Q)SAR Application Toolbox to Develop Chemical Categories According to the OECD Guidance on Grouping Chemicals

    This document provides guidance on how to use the OECD (Q)SAR Application Toolbox to build chemical categories according to the OECD Guidance on Grouping of Chemicals. It is part of an overall effort to provide guidance on the use of the (Q)SAR Application Toolbox.
     

  • 3-September-2014

    English

    Detailed Review Paper on the Use of Metabolising Systems for In Vitro Testing of Endocrine Disruptors

    Increasing incidents of disorders such as obesity/diabetes/metabolic syndrome, reproductive dysfunction, and neuro-developmental abnormalities in some human populations have raised concern that disruption of key endocrine-signaling pathways by exposure to environmental chemicals may be involved. This Detailed Review Paper describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption

  • 3-September-2014

    English

    The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins

    This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies databases containing test results related to those key events. AOPs can be incorporated into chemical categories-based assessments or integrated approaches for testing and assessment.

  • 3-September-2014

    English

    Current Approaches in the Statistical Analysis of Ecotoxicity Data - A guidance to application (annexes to this publication exist as a separate document)

    This document describes the main statistical methods used for analysis of data from ecotoxicological studies .

  • 3-September-2014

    English

    Guidance Document on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption

    This document is a tool to support regulatory authorities’ decisions on the hazard of specific chemicals when they receive test results from a Test Guideline (TG) or draft TG for the screening/testing of chemicals for endocrine disrupting properties. The contexts for these decisions will vary, depending on local legislation and practice, so the advice is worded in such a way as to permit flexible interpretation. It provides

  • 2-September-2014

    English

    Guidance on Developing Safety Performance Indicators For Industry

    This Guidance on Developing Safety Performance Indicators (“Guidance on SPI”) was prepared to assist enterprises that wish to implement and/or review Safety Performance Indicator Programmes. The three chapters in this Guidance are designed to help enterprises better understand safety performance indicators, and how to implement SPI Programmes. Specifically, Chapter 1 provides important background information on the Guidance and on

  • 2-September-2014

    English

    OECD Guidance on Pesticide Compliance and Enforcement Best Practices

    This Best Practices Guidance addresses compliance and enforcement issues as they relate to pesticides and associated health and environmental risks. The objective of this document is to provide guidance for promoting and monitoring compliance and for assessing and mitigating risks of non-compliance. It is targeted primarily at pesticide regulators, but may also interest policy makers as well as regulated parties (i.e. pesticide

  • 2-September-2014

    English

    Guidance Document on the Validation of (Quantitative) Structure-Activity Relationship [(Q)SAR] Models

    To keep (Q)SAR applications on a solid scientific foundation, an international effort to articulate principles for (Q)SAR technology and to develop a guidance document for use of (Q)SAR in regulatory applications. This document presents those principles and helpful guides for validating (Q)SAR technology for a variety of applications.

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