Structure-Activity Relationship (SAR) is an approach designed to find relationships between chemical structure (or structural-related properties) and biological activity (or target property) of studied compounds. As such it is the concept of linking chemical structure to a chemical property (e.g., water solubility) or biological activity including toxicity (e.g., fish acute mortality). Qualitative SARs and quantitative SARs,
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This document contains an analysis of data on 205 polymers to identify correlations between polymer characteristics and the potential for health or ecotoxicological concern.
L’OCDE vient de mettre au point un instrument novateur, la Boîte à outils sur les applications des (Q)SAR, pour évaluer les propriétés dangereuses des produits chimiques en analysant leur structure moléculaire.
Revised Guidance for Grouping of Chemicals. Considers closely related chemicals as a group, or cateogory, rather than as individual chemicals. In this approach, not every chemical needs to be tested for every endpoint.
The main electronic tool for data submission, evaluation and exchange used in the OECD Cooperative Chemicals Assessment Programme is the International Uniform Chemical Information Database (IUCLID). IUCLID is a software program for the administration of data on chemical substances.
The OECD Harmonised Templates are standard data formats for reporting reults of studies with chemicals in order to determine their properties and effects on human health and the environment.
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The reader will find that transparency in the validation process and objective determination of the reliability of (Q)SAR models are crucial to extending the regulatory acceptance of (Q)SAR models.<SPAN style="mso-spacerun:
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This case studies report is part of the OECD effort to develop guidance for regulatory applications of (Quantitative) Structure-Activity Relationship [(Q)SAR] models, and emphasizes the use of programme-specific case studies.
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This document describes a pilot phase for a process in which companies can notify to multiple jurisdictions and governments share information when conducting their reviews.
Emission estimation plays a key role in the risk assessments of chemical pollutants. These assessments have been facilitated with the use of Emission Scenario Documents (ESD’s) developed by member countries of the Organization for Economic Cooperation and Development (OECD).