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  • 13-January-2015

    English

    More about OECD Test Guidelines

    This page explains the background to the OECD Test Guidelines, the reason for their development, their applicability and how they can be accessed.

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  • 18-December-2014

    English

    Guidance Document for Describing Non-Guideline In Vitro Test Methods

    This guidance is intended to harmonise the way non-guideline in vitro test methods are described. This should in future facilitate an assessment of the relevance of test methods for biological activities and responses of interest, of the quality of data produced, irrespective of whether these tests are based on manual protocols or assay protocols adapted for use on automated platforms or high-throughput screening systems (HTS).

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  • 8-December-2014

    English, PDF, 726kb

  • 3-décembre-2014

    Français

    Génotoxicité des nanomatériaux manufacturés : Rapport de la réunion d' experts de l'OCDE

    Ce rapport contient les conclusions et recommandations d'un atelier OCDE sur la génotoxicité des nanomatériaux. Le sujet principal étant l'applicabilité des lignes directrices de l'OCDE (TG) existantes pour la sécurité chimique aux nanomatériaux.

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  • 14-November-2014

    English

    Guidance document on elements of a Pollutant Release and Transfer Registers (PRTR): Part 1

    OECD countries have developed PRTR system to track releases and transfers of potentially harmful chemicals. To improve PRTR system, OECD have analysed common elements (pollutants, sectors) in different PRTR systems, mainly focus on institutional arrangement. This serves as a common framework for different PRTR system, and supporting materials for a country that intends to develop or update its PRTR.

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  • 14-November-2014

    English

    Global Pollutant Release and Transfer Register (PRTR): Proposal for a harmonised list of pollutant

    PRTR have been established throughout the world to track releases and transfers of potentially harmful chemicals. But most of the PRTR systems were designed without considering comparability, each PRTR has its own requirement of reporting chemicals and sectors. To harmonise globally, OECD reviewed the reporting chemicals and sectors across PRTR systems and produced proposal for harmonised lists of reporting pollutants.

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  • 20-October-2014

    English

    OECD encourages the development of non-animal test methods for the detection of thyroid disrupters

    The OECD Advisory Group on Endocrine Disrupters Testing and Assessment met on 16-17 October 2014 in Paris to discuss the development and update of Test Guidelines and related documents for endocrine disrupters testing and assessment.

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  • 2-October-2014

    English

    Report of the pilot exercise on classifications for selected chemicals assessed at CoCAM

    The OECD has published a report on a pilot chemical classification exercise undertaken in 2013 and ‘14. Using a number of chemical assessments agreed in the OECD hazard assessment programme, reasons why classification proposals may differ were investigated. The report concludes on the main reasons for such differences, and recommends some measures to overcome some of them.

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  • 29-September-2014

    English

    New, updated and corrected OECD Test Guidelines for the testing of chemicals – 26 September 2014

    On 26 September 2014, the OECD Council adopted three new, five updated and one corrected OECD Test Guidelines for the testing of chemicals.

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  • 26-septembre-2014

    Français

    Essai n° 475: Essai d'aberration chromosomique sur moelle osseuse de mammifères

    L'essai d'aberration chromosomique in vivo sur mammifères est employé à l’identification des composés d'essai qui induisent des aberrations structurales dans des cellules de moelle osseuse d’animaux, généralement des rongeurs (rats, souris et hamsters chinois). Les aberrations structurales peuvent être de deux types : chromosomiques ou chromatidiques.Des animaux sont exposés à la substance d'essai (liquide ou solide) par une voie d'exposition appropriée (habituellement par gavage via une sonde gastrique ou d’une canule de tubage appropriée, ou par injection intrapéritonéale) et sont sacrifiés après des délais appropriés de traitement. Avant le sacrifice, les animaux sont traités avec un inhibiteur de fuseau. Des préparations chromosomiques sont alors faites à partir des cellules de moelle et colorées, et des cellules de métaphase sont analysées pour mettre en évidence les aberrations chromosomiques. Chacun des groupes traités et de contrôle doivent inclure au moins 5 animaux analysables par sexe. La dose de limite est 2000 de mg/kg pc/jour pour le traitement jusqu'à 14 jours, et de 1000 mg/kg pc/jour pour le traitement de plus de 14 jours.
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