Essais des produits chimiques

Specific Target Organ Toxicity/Repeated Exposure

 

Subacute Toxicity/Subchronic Toxicity

TG 407: Repeated dose 28-day oral toxicity study in rodents (2008)  (see also Endocrine Disruptors)
TG 408: Repeated dose 90-day oral toxicity study in rodents (1998)
TG 409: Repeated dose 90-day oral toxicity study in non-rodents (1998)
TG 410: Repeated dose dermal toxicity: 21/28-day study (1981)
TG 411: Subchronic dermal toxicity: 90-day study (1981)
TG 412: Subacute inhalation toxicity: 28-day study (1981)


TG 413: Subchronic inhalation toxicity: 90-day study (1981)
•    No 125: Guidance document on histopathology for inhalation toxicity studies, supporting TG 412
                      (Subacute inhalation toxicity: 28-day study) and TG 413 (Subchronic inhalation toxicity: 90-day study)


General documents:

No 32: Guidance notes for analysis and evaluation of repeat-dose toxicity studies
No 106: Guidance document for histologic evaluation of endocrine and reproductive tests in rodents


Chronic Toxicity

TG 452: Chronic toxicity studies (2009)


TG 453: Combined chronic toxicity/carcinogenicity studies (2009)
•    No 35: Guidance notes for analysis and evaluation of chronic toxicity and carcinogenicity studies
•    No 116: Guidance document on the conduct and design of chronic toxicity and carcinogenicity studies,
                     supporting test guidelines 451, 452 and 453 - second edition (2011)

 

Documents connexes

 

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