Essais des produits chimiques

Section 4: Health Effects


important notice

The draft Test Guidelines are not part of Mutual Acceptance of Data (MAD); consult with national authorities before using the draft Test Guidelines.

NEW DEADLINE for comments

*For Draft Detailed Review Paper (DRP) on Pathway Signalling please click on this link *


Deadline for comment: 31 January 2020

Revised Draft Test Guideline for Androgen Receptor Transaction


Deadline for comment: 6 January 2020

Draft Updated TG 437 on the BCOP test method for identifying Chemicals inducing serious eye damage and chemicals not requiring classification


Deadline for comment: 20 November 2019

Draft Test Guideline on the Determination of cytochrome P450 (CYP) enzyme activity induction using differentiated human hepatic cells


Deadline for comment: 15 November 2019

Draft Updated Test Guideline 491 on Short Time Exposure In Vitro Test Method For Eye Irritation


Deadline for comment: 1 November 2019

Draft guideline for defined approaches for skin sensitisation 

Draft supporting document for defined approaches for skin sensitisation

Deadline for comment: 30 October 2019

Draft TG 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays


Deadline for comment: 13 September 2019

Draft TG: Androgen receptor (AR) mediated stably transfected transcriptional activation assay to detect AR agonist and antagonist using 22Rvl/MMTV GR-KO cell line



Draft Proposal for a New Performance Based TG - Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method (PDF)

Draft Performance Standards for New Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method  (PDF)
Multi-study Validation Trial for Cytochrome P450 Induction Providing a Reliable Human Metabolically Competent Standard Model or Method Using the Human Cryopreserved Primary Hepatocytes and the Human Cryopreserved HepaRG® Cell Line (PDF)
Deadline for public comments*: 21 October 2014

Revised draft TG in vitro Macromolecular Test Method for Eye Hazard Potential

Revised draft Performance Standards for in vitro Macromolecular Test Method

Draft Updated Test Guideline 488 on Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

Draft Guideline for Defined Approaches (DAs) for Skin Sensitisation 

Supporting Document for the draft Guideline for DAs for Skin Sensitisation


further reading

* Comments should be sent to the Secretariat by National Coordinators by the indicated date. Anyone who would like to contribute to a commenting round is invited to contact their National Coordinator beforehand to discuss together of a timeframe for comment submission.



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