Partager

Essais des produits chimiques

Section 4: Health Effects

 

important notice

The draft Test Guidelines are not part of Mutual Acceptance of Data (MAD); consult with national authorities before using the draft Test Guidelines.

NEW DEADLINE for comments

Deadline for comment: 13 September 2019

Draft TG: Androgen receptor (AR) mediated stably transfected transcriptional activation assay to detect AR agonist and antagonist using 22Rvl/MMTV GR-KO cell line

 

Deadline for comment: 13 September 2019

Draft TG 458: Stably Transfected Androgen Receptor Transactivation Assays for Detection of Androgenic Agonist and Antagonist Activity of Chemicals

 

RECENT DRAFT GUIDELINES

Draft Proposal for a New Performance Based TG - Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method (PDF)

Draft Performance Standards for New Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method  (PDF)
Multi-study Validation Trial for Cytochrome P450 Induction Providing a Reliable Human Metabolically Competent Standard Model or Method Using the Human Cryopreserved Primary Hepatocytes and the Human Cryopreserved HepaRG® Cell Line (PDF)
Deadline for public comments*: 21 October 2014

Revised draft TG in vitro Macromolecular Test Method for Eye Hazard Potential

Revised draft Performance Standards for in vitro Macromolecular Test Method

Draft Updated Test Guideline 488 on Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

Draft Guideline for Defined Approaches (DAs) for Skin Sensitisation 

Supporting Document for the draft Guideline for DAs for Skin Sensitisation

 

further reading

* Comments should be sent to the Secretariat by National Coordinators by the indicated date. Anyone who would like to contribute to a commenting round is invited to contact their National Coordinator beforehand to discuss together of a timeframe for comment submission.

 

 

Documents connexes

 

Also AvailableEgalement disponible(s)