Essais des produits chimiques

Level 4: In vivo Assays Providing Data of Adverse Effects on Endocrine Relevant Endpoints


Only endocrine disruptors related documents are included here. Please refer to the description by types of hazard for any other documents associated to the Test Guidelines mentioned below.

Repeated Dose 28-day Study

TG 407: Repeated dose 28-day oral toxicity study in rodents (2008)
•    No 59: Report of the validation of the updated test guideline 407 - repeat dose 28-day oral toxicity study in laboratory rats
•    No 81: Summary report of the validation peer review for the updated test guideline 407, and agreement of the Working
                  Group of the National Coordinators of the Test Guidelines Programme on the follow-up of this report

General Documents

No 106: Guidance document for histologic evaluation of endocrine and reproductive tests in rodents  Part 1, Part 2
      => This document provides guidance for histopathological examinations and is also applicable to other test guidelines.

Other Test Guidelines

TG 408: Repeated dose 90-day oral toxicity study in rodents (1998)
TG 415: One-generation reproduction toxicity study (1983)
TG 414: Prenatal development toxicity study (2001)
TG 421: Reproduction/developmental toxicity screening test (1995)
TG 422: Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (1996)
TG 426: Developmental neurotoxicity study (2007)
TG 451: Carcinogenicity studies (2009)
TG 453: Combined chronic toxicity/carcinogenicity studies (2009)


Documents connexes