By Date


  • 7-November-2016

    English

    Testing Programme of Manufactured Nanomaterials

    The safety of Manufactured Nanomaterials is an important concern impacting regulatory bodies throughout the world. Due to their size, Manufactured Nanomaterials may require additional testing beyond the standard suite of tests used for other chemicals, to ensure that the impact on human health and the environment is fully understood - download Manufactured Nanomaterials Dossiers or search for Tested Endpoints.

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  • 31-October-2016

    English

    Draft Guidance and Review Documents/Monographs

    The Draft Guidance Document on Good In Vitro Method Practices (Givimp) for the Development and Implementation of In Vitro Methods for Regulatory Use in Human Safety Assessment is open for public comments until 16 December 2016.

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  • 28-October-2016

    English

    Integrated Approaches to Testing and Assessment (IATA)

    Guidance on principles for reporting defined approaches within IATA and an associated template have been published. A second guidance document illustrates how the reporting templates can be used to document a number of defined approaches (and information sources used within) in the area of skin sensitisation. This is exemplified via 12 case studies for skin sensitisation.

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  • 18-October-2016

    English

    Developmental neurotoxicity: OECD/EFSA experts discuss non-animal test methods

    Participants from 15 countries attended the Workshop on Developmental Neurotoxicity: The use of non-animal test methods for regulatory purposes” on 18 October 2016, in Belgium. The event, co-organised by the OECD and the European Food Safety Authority (EFSA), focused on opportunities and challenges related to alternative methods for testing and assessing the DNT potential of chemicals.

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  • 20-September-2016

    English

    OECD publishes new and updated Test Guidelines for effects on human health and on environmental species

    The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. Every year new and updated Test Guidelines are adopted to meet the regulatory needs in OECD member countries. The most recent Test Guidelines were adopted in July 2016.

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  • 15-September-2016

    English

    Introduction to Pollutant Release and Transfer Registers (PRTRs)

    A Pollutant Release and Transfer Register (PRTR) is a publicly accessible database or inventory of chemicals or pollutants released to air, water and soil and transferred off-site for treatment. Find out more: What hazardous chemical substances and pollutants are being released to the environment or transferred off-site? How much is being released or transferred off-site over time? Where the releases occur? and by whom?

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  • 2-September-2016

    English

    Section 4: Health Effects

    New deadlines for comments: Draft updated TG 492 on RhCE for eye hazard potential and draft updated performance standards for the validation of similar methods. The deadline for public comments of 3 October 2016.

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  • 5-August-2016

    English

    IOMC Toolbox for Chemical Accidents

    The IOMC Toolbox is a tool enabling countries to identify the most appropriate and efficient actions to solve specific national problems related to chemicals management.

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  • 5-August-2016

    English

    Environment, health and safety briefs

    These four current EHS briefs show the objectives, outcomes and benefits of the Pesticides, (Q)SARs, MAD and PFCs programmes.

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  • 29-juillet-2016

    Français

    Essai n° 242: Essai de reproduction chez Potamopyrgus antipodarum

    Le test de reproduction chez l'espèce Potamopyrgus antipodarum (hydrobie des antipodes) a pour objet l’évaluation des effets potentiels d’une exposition prolongée aux produits chimiques sur la reproduction et la survie de lignées parthénogénétiques de cet escargot d’eau douce. À cet effet, on expose des femelles adultes à une gamme de concentrations du produit chimique testé. Le produit chimique testé est mélangé à de l’eau de dilution (eau reconstituée), ajouté aux béchers destinés à l’essai, puis des escargots adultes sont placés dans les béchers. Si l’essai porte sur des « produits chimiques difficiles » (c’est-à-dire volatiles, instables, facilement biodégradables ou adsorbants), il est possible de conduire l’essai en conditions dynamiques, en s’écartant de la conception semi-statique avec renouvellement du milieu à intervalles réguliers. On étudie la survie de P. antipodarum au cours de la période d’exposition de 28 jours, et la reproduction à l’issue des 28 jours d’exposition au produit chimique testé. La reproduction est mesurée par le nombre d'embryons contenus dans la poche embryonnaire (sans distinction du stade de développement) à la fin de la période d'exposition de 28 jours. L’effet toxique du produit chimique testé sur le nombre d’embryons est exprimé sous la forme d’une CEx, établie en appliquant aux données un modèle d’ajustement adapté afin d'estimer la concentration qui produirait une réduction de x % du nombre d’embryons. Il est également possible d’exprimer l’effet toxique du produit testé par la concentration sans effet observé et la concentration minimale avec effet observé (CSEO/CMEO).

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