Publications & Documents


  • 8-September-2016

    English

    Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists

    This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays). It comprises mechanistically and functionally similar test methods for the identification of estrogen receptor agonists and antagonists and should facilitate the development of new similar or modified test methods. The two reference test methods that provide the basis for this PBTG are: the Stably Transfected TA (STTA) assay using the (h) ERα-HeLa-9903 cell line, derived from a human cervical tumor, and the BG1Luc ER TA assay using the BG1Luc-4E2 cell line, derived from a human ovarian adenocarcinoma. The cell lines used in these assays express ER and have been stably transfected with an ER responsive luciferase reporter gene. The assays are used to identify chemicals that activate (i.e. act as agonists) and also suppress (i.e. act as antagonists) ER- dependent transcription. ER are activated following ligand binding, after which the receptor-ligand complex binds to specific DNA response elements and transactivates the reporter gene, resulting in increased cellular expression of a marker enzyme (e.g. luciferase in luciferase based systems). The enzyme then transforms the substrate to a bioluminescent product that can be quantitatively measured with a luminometer. These test methods are being proposed for screening and prioritisation purposes, but also provide mechanistic information that can be used in a weight of evidence approach.

  • 6-September-2016

    English

    Conference on Transition to the green economy

    This event, with involvement from the OECD, on 6-7 September 2016, is of major strategic nature during the Slovak Presidency of the European Council. Its ambition is to improve understanding of the green economy concept, identify conclusions and pathways for transition as well as to involve and mobilise various actors and stakeholders in the discussions of possible future actions.

    Related Documents
  • 5-September-2016

    English

    OECD welcomes ground-breaking peer reviews by China and US of their fossil fuel subsidies

    The OECD has welcomed the release by China and the US of peer reviews of their fossil fuel subsidies.

    Related Documents
  • 29-August-2016

    English

    Putting water security at the heart of sustainable development

    Today, the challenge of water security is global and it is growing. We estimate that by 2050, over 40% of the global population will live under severe water stress; and as global population increases, so will tensions among different water uses.

  • 26-August-2016

    English

    The climate scientist and the teacher - Insights blog

    Climate change is not just about a change in climate towards hotter, wetter, and drier conditions, but also about an increase in the variability of the climate, as well as in the number and severity of extreme events.

    Related Documents
  • 25-August-2016

    English

    Environmental Zoning and Urban Development: Natural Regional Parks in France - Environment Working Paper

    This study provides an empirical analysis of the effects of environmental zoning on urban development. It focuses on the case of Natural Regional Parks (NRPs) in France. Of the environmental zoning instruments used in France, NRPs extend over the widest physical area. Three potential side-effects of NRPs on urban development in the regulated area are investigated.

    Related Documents
  • 25-August-2016

    English

    Climate Impacts in the Sahel and West Africa: Role of Climate Science in Policy Making - West African Papers

    This paper reviews the latest climate projections for West Africa and considers alternative ways in which the knowledge generated from climate science can be understood in the context of preparing for an uncertain future that provides practical help for decision makers.

    Related Documents
  • 22-August-2016

    English

    Climate change and development

    The OECD DAC aims to assist countries to implement effective and efficient policies to address climate change by conducting policy-relevant research and analysis related to climate change adaptation, financing and measuring aid in support of climate change mitigation and adaptation.

    Related Documents
  • 12-August-2016

    English

    Collaborative Strategies for In-Country Shared Value Creation - Framework for Extractive Projects

    The Framework is an operational tool offering guidance on actionable steps for harnessing non-renewable natural resources to build competitive, diversifi ed, and sustainable economies in a scalable manner. It presents a practical guide on how host governments, extractives industries and civil society can work together in a structured and systematic way to enable in-country shared value creation and advance the 2030 Agenda for Sustainable Development. The Framework transcends sectoral boundaries and focuses on strategies to foster coherence, sequencing, and effective co-ordination for integrated policymaking, and suggests monitoring and evaluation mechanisms to assess progress and impact over time.
    The actionable steps are addressed to governments, industry, and civil society clearly articulating their respective roles for improved collaboration, mutual respect and accountability.

  • 9-August-2016

    English

    Implications of water scarcity for economic growth - Environment Working Paper

    Water is linked to many economic activities, and there are complex channels through which water affects economic growth. The purpose of this report is to provide background information useful for a quantitative global assessment of the impact of water scarcity on growth using a multi-region, recursive-dynamic, Computable General Equilibrium (CGE) model.

    Related Documents
  • << < 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 | 114 | 115 | 116 | 117 | 118 | 119 | 120 | 121 | 122 | 123 | 124 | 125 | 126 | 127 | 128 | 129 | 130 | 131 | 132 | 133 | 134 | 135 | 136 | 137 | 138 | 139 | 140 | 141 | 142 | 143 | 144 | 145 | 146 | 147 | 148 | 149 | 150 | 151 | 152 | 153 | 154 | 155 | 156 | 157 | 158 | 159 | 160 | 161 | 162 | 163 | 164 | 165 | 166 | 167 | 168 | 169 | 170 | 171 | 172 | 173 > >>