Latest Documents


  • 7-September-2009

    English

    Test No. 451: Carcinogenicity Studies

    The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test substance by an appropriate route of administration.

    This Test Guideline is intended primarily for use with rats and mice, and for oral administration. Both sexes should be used. Each dose group and concurrent

  • 7-September-2009

    English

    Test No. 412: Subacute Inhalation Toxicity: 28-Day Study

    This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity
    by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data for quantitative inhalation risk assessments.

    Groups of at least 5 male and 5 female rodents are exposed 6 hours per day for 28 days to a) the test article at three or more concentration levels, b)

  • 7-September-2009

    English

    Test No. 441: Hershberger Bioassay in Rats - A Short-term Screening Assay for (Anti)Androgenic Properties

    The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the changes in weight of five androgen-dependent tissues in the castrate-peripubertal male rat: the ventral prostate, seminal vesicle (plus fluids and coagulating glands), levator

  • 7-September-2009

    English

    Test No. 403: Acute Inhalation Toxicity

    This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation.

    The revised Test Guideline describes two studies: a traditional LC50 protocol and a Concentration x Time (C x t) protocol. It can be used to estimate a median lethal concentration (LC50), non-lethal threshold concentration (LC01) and slope, and to

  • 7-September-2009

    English

    Test No. 509: Crop Field Trial

    Crop field trials are conducted to determine the magnitude of the pesticide residue in or on raw agricultural commodities, including feed items, and should be designed to reflect pesticide use patterns that lead to the highest possible residues.

    Objectives of crop field trials are to: (1) quantify the expected range of residue(s) in crop commodities following treatment according to the proposed or established good

  • 7-September-2009

    English

    Test No. 229: Fish Short Term Reproduction Assay

    This Test Guideline describes an in vivo screening assay for fish reproduction where sexually mature male and spawning female fish are held together and exposed to a chemical during a limited part of their life-cycle (21 days). The short term reproduction assay was validated in the fathead minnow (Pimephales promelas) and this is the recommended species. The assay is run with three test chemical concentrations and the necessary

  • 7-September-2009

    English

    Test No. 302C: Inherent Biodegradability: Modified MITI Test (II)

    This Test Guideline describes the modified MITI test (II). This test permits the measurement of the Biochemical Oxygen Demand (BOD) and the analysis of residual chemicals in order to evaluate the inherent biodegradability of chemical substances which have been found by the Standard MITI Method (I) to be low degradable.

    An automated closed-system oxygen consumption measuring apparatus (BOD-meter) is used. Chemicals to be

  • 4-September-2009

    English

    Incentives for CO2 Emission Reductions in Current Motor Vehicle Taxes

    This paper compares CO2-related tax rate differentiation in motor vehicle taxes in OECD member countries, drawing on information available in the OECD/EEA database on instruments used for environmental policy.

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  • 3-September-2009

    English

    Incentives for CO2 Emission Reductions in Current Motor Vehicle Taxes

    The present paper compares the use of CO2 or energy efficiency tax rate differentiation in OECD countries at present.

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  • 27-August-2009

    English

    Guidance Manual for the Testing of Manufactured Nanomaterials: OECD's Sponsorship Programme: Number 14

    This Guidance Manual for the Testing of Manufactured Nanomaterials, is a “living document” and as such, it will be updated and amended in an iterative manner based upon knowledge accumulation as the testing programme and Dossier Development Plans (DDPs) work progresses.

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