Latest Documents


  • 22-July-2010

    English

    Test No. 209: Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation)

    This Test Guideline is designed to assess the effects of a substance on micro-organisms from activated sludge of waste-water treatment plants by measuring their respiration rate (carbon and/or ammonium oxidation) as oxygen consumption. The test results may also serve as an indicator of suitable non-inhibitory concentrations of test substances to be used in biodegradability tests. The test allows the determination of ECx and/or NOEC

  • 22-July-2010

    English

    Test No. 439: In Vitro Skin Irritation - Reconstructed Human Epidermis Test Method

    This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.  It is based on reconstructed human epidermis (RhE), which in its overall design closely mimics the biochemical and physiological properties of the upper parts of the human skin. Cell

  • 22-July-2010

    English

    Test No. 417: Toxicokinetics

    This Test Guideline describes in vivo studies that provide information on mass balance, absorption, bioavailability, tissue distribution, metabolism, excretion, and basic toxicokinetic parameters [e.g. AUC], as well as supplemental approaches that may provide useful information on toxicokinetics. Information from toxicokinetic studies helps to relate concentration or dose to the observed toxicity and to understand its mechanism of

  • 22-July-2010

    English

    Test No. 317: Bioaccumulation in Terrestrial Oligochaetes

    This Test Guideline describes procedures designed to assess bioaccumulation of chemicals in soil oligochaetes. The parameters which characterise the bioaccumulation of a substance include the bioaccumulation factor (BAF), the uptake rate constant (ks) and the elimination rate constant (ke). The test consists of two phases: the uptake (exposure) phase and the elimination (post-exposure) phase. An elimination phase is always required

  • 22-July-2010

    English

    Test No. 429: Skin Sensitisation - Local Lymph Node Assay

    The basic principle underlying the Local Lymph Node Assay (LLNA) in mouse is that sensitizers induce a primary proliferation of lymphocytes in the auricular lymph nodes draining the site of chemical application. This proliferation is proportional to the dose applied and provides a measurement of sensitisation. The method described is based on the use of radioactive labelling to measure cell proliferation. A minimum of four animals

  • 22-July-2010

    English

    Test No. 442A: Skin Sensitization - Local Lymph Node Assay: DA

    The Local Lymph Node Assay: DA (LLNA: DA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular lymph nodes. The method, described in mouse (CBA/J strain), is based on measurement of the adenosine triphosphate (ATP) content by bioluminescence as an indicator of this proliferation. A minimum of four

  • 22-July-2010

    English

    Test No. 223: Avian Acute Oral Toxicity Test

    This Test Guideline describes procedures designed to estimate the acute oral toxicity of substances to birds, and it provides three testing options: (1) limit dose test, (2) LD50-slope test, and (3) LD50-only test. The LD50-slope and LD50-only options are sequential testing procedures. The test method selected will depend on whether or not a definitive median dose (LD50) and slope of the dose-response curve are both needed. The

  • 15-July-2010

    English, , 1,581kb

    Climate policy and technological innovation and transfer: an overview of trends and recent empirical results

    Technological innovation can lower the cost of achieving environmental objectives. As such, understanding the linkages between environmental policy and technological innovation in achieving environmental objectives is important.

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  • 7-July-2010

    English

    Current Developments/Activities on the Safety of Manufactured Nanomaterials

    This document provides information on current/planned activities related to the safety of manufactured nanomaterials in OECD member and non-member countries that attended at the 7th meeting of OECD’s Working Party on Manufactured Nanomaterials (Paris France, 7-9 July 2010).

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  • 7-July-2010

    English

    Guidance Manual for the Testing of Manufactured Nanomaterials: OECD Sponsorship Programme: First Revision

    The objective of this document, Guidance Manual for the Testing of Manufactured Nanomaterials, is to assist sponsors in the development of Dossier Development Plans (DDPs).

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