Latest Documents


28-July-2011

English

Case Study: Assessment of an Extended Chemical Category, the Short-chain Methacrylates, Targeted on Bioaccumulation

This case study intends to illustrate this concept for the short chain methacrylates,originally composed of four chemicals, for the bioaccumulation endpoint. The OECD QSAR Toolbox identified about 160 chemicals potentially falling within the applicability domain of the original category, and the hypothesis tested in this case study is the possibility to predict the bioaccumulation potential for untested members of the category. The

28-July-2011

English

Harmonising Climate Risk Management: Adaptation Screening and Assessment Tools for Development Co-operation - Environment Working Paper No. 36

This Working Paper analyses set of tools targeted to screen climate change risks and focuses on the need to consider the experiences of users as well as developers, and to investigate the extent to which tools are meeting user needs.

Related Documents

27-July-2011

English

Test No. 234: Fish Sexual Development Test

This Test Guideline describes an assay that assesses early life-stage effects and potential adverse consequences of putative endocrine disrupting chemicals (e.g. oestrogens, androgens and steroidogenesis inhibitors) on fish sexual development. In the test, fish are exposed, from newly fertilized egg until the completion of sexual differentiation at about 60 days post hatch, to at least three concentrations of the test substance

27-July-2011

English

Test No. 456: H295R Steroidogenesis Assay

This Test Guideline describes an in vitro screen for chemical effects on steroidogenesis, specifically the production of 17ß-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma cell line, used for the assay, expresses genes that encode for all the key enzymes for steroidogenesis. After an acclimation period of 24 h in multi-well plates, cells are exposed for 48 h to seven concentrations of the test chemical in at

27-July-2011

English

Test No. 201: Freshwater Alga and Cyanobacteria, Growth Inhibition Test

The purpose of this test is to determine the effects of a substance on the growth of freshwater microalgae and/or cyanobacteria. Exponentially growing test organisms are exposed to the test substance in batch cultures over a period of normally 72 hours.

The system response is the reduction of growth in a series of algal cultures exposed to, at least, five concentrations of a test substance. Three replicates at each test

27-July-2011

English

Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The transgenes contain reporter genes for the detection of various types of mutations induced by test substances. A negative control group and a minimum of 3 treatment groups of

27-July-2011

English

Test No. 235: Chironomus sp., Acute Immobilisation Test

This Test Guideline describes an acute immobilisation assay on chronomids and is designed to complement existing Test Guidelines for chironomid chronic toxicity assays (TG 218, 219 and 233). The test method is based on TG 202: Daphnia sp. Acute Immobilisation Test. First instar Chironomus sp. larvae are exposed to a range of concentrations of the test substance in water-only vessels for a period of 48 hours. C. riparius is the

27-July-2011

English

Test No. 443: Extended One-Generation Reproductive Toxicity Study

This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and young and adult offspring. In the assay, sexually-mature males and females rodents (parental (P) generation) are exposed to graduated doses of the test substance starting 2 weeks before

26-July-2011

English

Agricultural Pesticides

The Pesticide Programme of the OECD looks to help governments co-operate in assessing and reducing the risks of agricultural pesticides. The OECD encourages governments to share the work of pesticide registration and develops tools to monitor and minimise pesticide risk to health and the environment.

26-July-2011

English

Biocides

The objective of the OECD Biocide Programme is to attain a harmonised approach in the regulation of biocides in all OECD countries. The OECD is thus working on harmonising the main data requirements for biocides and the methodologies for the interpretation of these data.

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