Latest Documents


  • 6-July-2018

    English

    OECD action on biodiversity and ecosystems

    The OECD work on biodiversity promotes policies that are environmentally effective, economically efficient and distrubtionally equitable. OECD work on biodiversity and ecosystems also supports the work of the UN Convention on Biological Biodiversity. Find out more on how the OECD is supporting action on biodiversity.

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  • 5-July-2018

    English

    Chemical Safety and Biotechnology News

    This Chemical Safety and Biosafety news release provides an update on the recent projects, events and publications.

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  • 2-July-2018

    English

    OECD action on climate change

    The OECD climate change work is focusing on how to move countries to low-emissions and climate resilient pathways, and how to improve the effectiveness of the global climate regime. Explore the policy areas to access the latest OECD work in each area and find out more on how the OECD is supporting action on climate change.

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  • 28-June-2018

    English

    Genome Editing: Applications in Agriculture

    The OECD Conference on Genome Editing: Applications in Agriculture – Implications for Health, Environment and Regulation will explore the regulatory considerations raised by genome edited products, with the aim to favour a coherent policy approach to facilitate innovation involving genome editing. More information on the programme and the speakers.

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  • 28-June-2018

    English

    OECD Guidelines for the Testing of Chemicals

    The OECD adopted a set of new and updated Test Guidelines for chemicals safety testing to keep pace with scientific progress. These Test Guidelines are readily usable tools for members and Mutual Acceptance Data (MAD) adhering countries.

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  • 28-June-2018

    English

    OECD Environmental Performance Reviews: Hungary 2018

    Hungary has made significant progress in decoupling its output growth from main environmental pressures, largely due to implementing requirements of EU directives. However, greenhouse gas emissions have started to pick up with the recent rebound of economic activity. Local air quality has not improved significantly, and water quality remains at risk. Important institutional challenges impede more effective implementation of environmental laws and policies. Hungary can accelerate the transition towards a low-carbon and greener economy, particularly by investing in residential energy efficiency and sound waste and material management, and better mainstreaming of biodiversity protection into sectoral economic policies.This is the third Environmental Performance Review of Hungary. It evaluates progress towards sustainable development and green growth, with special features on waste, material management and circular economy, and biodiversity.
  • 27-June-2018

    English

    Test No. 442B: Skin Sensitization - Local Lymph Node Assay: BrdU-ELISA

    The Local Lymph Node Assay: BrdU-ELISA (LLNA:BrdU-ELISA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular lymph nodes. The method described in mouse  is based on the use of measuring 5-bromo-2-deoxyuridine (BrdU) content, an analogue of thymidine, as an indicator of this proliferation. A minimum of four animals is used per dose group, with a minimum of three concentrations of the test substance, plus a concurrent negative control group and a positive control group. The experimental schedule is during 6 days. Thereafter, the animals are killed and a single cell suspension of lymph node cells (LNC) is prepared. The procedure for preparing the LNC is crucial, in particular for the small lymph nodes in NC animals. Then the BrdU content in DNA of lymphocytes is measured by ELISA using a commercial kit of by Flow Cytometry (FCM). This study includes: measurements (weighing, BrdU) and clinical daily observations. The results are expressed as the Stimulation Index (SI) obtained by calculation from the mean BrdU labelling index. The SI should be ≥1.6 for the ELISA method or ≥2.7 for the FCM method for identifying the test material as a potential skin sensitizer. 
  • 27-June-2018

    English

    Test No. 319B: Determination of in vitro intrinsic clearance using rainbow trout liver S9 sub-cellular fraction (RT-S9)

    The Test Guideline (TG) describes the use of liver S9 sub-cellular fraction (RT-S9) of rainbow trout (Oncorhynchus mykiss) as a metabolising system to determine the clearance (CL, IN VITRO, INT ) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the RT-S9 incubation medium initiates the reaction. In order to collect samples at various time points, the reaction is terminated by transferring an aliquot of the medium to a stopping solution. The decrease of the test chemical concentration from the incubation vial is measured with a validated analytical method and used to determine the CL, IN VITRO, INT.  The value obtained can then be used to improve in silico predictions of the test chemical bioaccumulation in fish.
  • 27-June-2018

    English

    Test No. 443: Extended One-Generation Reproductive Toxicity Study

    This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and young and adult offspring. In the assay, sexually-mature males and females rodents (parental (P) generation) are exposed to graduated doses of the test substance starting 2 weeks before mating and continuously through mating, gestation and weaning of their pups (F1 generation). At weaning, pups are selected and assigned to cohorts of animals for reproductive/developmental toxicity testing (cohort 1), developmental neurotoxicity testing (cohort 2) and developmental immunotoxicity testing (cohort 3). The F1 offspring receive further treatment with the test substance from weaning to adulthood. Clinical observations and pathology examinations are performed on all animals for signs of toxicity, with special emphasis on the integrity and performance of the male and female reproductive systems and the health, growth, development and function of the offspring. Part of cohort 1 (cohort 1B) may be extended to include an F2 generation; in this case, procedures for F1 animals will be similar to those for the P animals.
  • 27-June-2018

    English

    Test No. 413: Subchronic Inhalation Toxicity: 90-day Study

    This revised Test Guideline 413 (TG 413) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a period of 90 days, and to provide data for quantitative inhalation risk assessments.  It was updated in 2017 to enable the testing and characterisation of effects of nanomaterials tested.Groups of at least 10 male and 10 female rodents are exposed 6 hours per day for 90 days to a) the test chemical at three or more concentration levels, b) filtered air (negative control), and/or c) the vehicle (vehicle control). Animals are generally exposed 5 days per week but exposure for 7 days per week is also allowed. Males and females are always tested, but they may be exposed at different concentration levels if it is known that one sex is more susceptible to a given test chemical. The results of the study include measurement and daily and detailed observations (haematology and clinical chemistry), as well as ophthalmology, gross pathology, organ weights, and histopathology. This Test Guideline allows the flexibility to include satellite (reversibility) groups, interim sacrifices, bronchoalveolar lavage (BAL), lung burden (LB) for particles, neurologic tests, and additional clinical pathology and histopathological evaluations in order to better characterize the toxicity of a test chemical.
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