Latest Documents


  • 3-September-2014

    English

    Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors

    This document describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption and whose disruption could contribute to increasing incidents of some disorders in humans and wildlife populations, such as obesity/diabetes/metabolic syndrome, reproductive dysfunction, and neuro-developmental abnormalities. Assays and endpoints are described that could be used in new or existing OECD Test

  • 3-September-2014

    English

    The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins

    This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies databases containing test results related to those key events. AOPs can be incorporated into chemical categories-based assessments or integrated approaches for testing and assessment.

  • 3-September-2014

    English

    Guidance Document on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption

    This document is a tool to support regulatory authorities’ decisions on the hazard of specific chemicals when they receive test results from a Test Guideline (TG) or draft TG for the screening/testing of chemicals for endocrine disrupting properties. The contexts for these decisions will vary, depending on local legislation and practice, so the advice is worded in such a way as to permit flexible interpretation. It provides

  • 3-September-2014

    English

    Detailed Review Paper (DRP) on Molluscs Life-cycle Toxicity Testing

    This paper reviews what is known about the responses of molluscs to endocrine disrupting chemicals (EDCs), to consider whether it would be desirable and feasible to standardise mollusc-based partial- and full-lifecycle tests that are sensitive to EDCs and to other chemicals, and if so, to recommend suitable methods for optimisation and validation.

  • 3-September-2014

    English

    The Guidance Document for Using the OECD (Q)SAR Application Toolbox to Develop Chemical Categories According to the OECD Guidance on Grouping Chemicals

    This document provides guidance on how to use the OECD (Q)SAR Application Toolbox to build chemical categories according to the OECD Guidance on Grouping of Chemicals. It is part of an overall effort to provide guidance on the use of the (Q)SAR Application Toolbox.
     

  • 3-September-2014

    English

    Current Approaches in the Statistical Analysis of Ecotoxicity Data - A guidance to application (annexes to this publication exist as a separate document)

    This document describes the main statistical methods used for analysis of data from ecotoxicological studies .

  • 3-September-2014

    English

    Detailed Review Paper on the Use of Metabolising Systems for In Vitro Testing of Endocrine Disruptors

    Increasing incidents of disorders such as obesity/diabetes/metabolic syndrome, reproductive dysfunction, and neuro-developmental abnormalities in some human populations have raised concern that disruption of key endocrine-signaling pathways by exposure to environmental chemicals may be involved. This Detailed Review Paper describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption

  • 3-September-2014

    English

    Fish Toxicity Testing Framework

    This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant. A review of regulatory needs for fish tests under various jurisdictions in OECD countries is provided in Chapter 2, followed by a review of statistical issues and general test considerations in Chapters 3 and 4, respectively. The

  • 2-September-2014

    English

    Transport and Storage of Chemicals

    This OECD Emission Scenario Document (ESD) provides information on the sources and release pathways of chemicals during their transport and storage in a wide range of industries, to help estimate releases of chemicals into the environment. This ESD covers the transport and storage of chemicals either as pure chemicals or as components of finished products. However, it does not consider the following: mixed waste streams,

  • 2-September-2014

    English

    Insecticides, Acaricides and Products to Control Other Arthropods for Household and Professional Uses

    This Emission Scenario Document (ESD) is intended to provide information to be used for risk
    assessment for active substances and products used as biocidal (i.e. non agricultural) insecticides, acaricides and products to control other arthropods (in the EU, product type 18 [PT18] c).

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