Latest Documents


  • 16-October-2008

    English

    Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents

    This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level daily during 28 days). This Guideline is intended primarily for use with rodents (rat preferably). At least 10 animals (5 female and 5 male) should be used for each dose level. Three tests groups, at least, should be used. The test compound is administered by gavage or via the diet or drinking water. A limit test may be performed if no effects would be expected at a dose of 1000 mg/kg bw/d. The report of this study will include results from clinical and functional observations, body weight and food/water consumption measurements, hematology and clinical biochemistry; as well as gross necropsy and histopathology.

  • 16-October-2008

    English

    Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure

    The method permits estimation of an LD50 with a confidence interval and the results allow a substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals.

    It is easiest to apply to materials that produce death within couple of days. This Test Guideline is intended for use with rodents (rat female preferably). There are a limit test and a main test. The limit test can be used efficiently to identify chemicals that are likely to have low toxicity. The test substance is administered generally in a single dose by gavage to animals fasted prior to dosing. Single animals are dosed in sequence usually at 48h intervals. The first animal is dosed a step below the best preliminary estimates of the LD50. The second animal receives a lower dose (if the first animal dies) or a higher dose (if the first animal survives). Animals are observed with a special attention given during the first 4 hours and daily thereafter, for a total of 14 days generally. Weights Animals should be determined at least weekly. All the animals should be subjected to gross necropsy. Globally the LD50 is calculated using the maximum likelihood method. Following this, it may be possible to compute interval estimates for the LD50; most narrow is the interval and better is LD50 estimation.

    Software to be used with TG 425, 432, 455. Click here. Software not part of the Mutual Acceptance of Data.

  • 15-October-2008

    English

    Costs of Inaction on Key Environmental Challenges (2008)

    Countries today face numerous environmental challenges, such as climate change, air and water pollution, natural resource management, natural disasters and industrial accidents.

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  • 10-October-2008

    English

    OECD Roundtable on Urban Strategy of Mayors and Ministers on “Competitive Cities and Climate Change”: Remarks by Angel Gurría

    Given that the majority of the world’s population lives in cities accounting for 60 to 80 percent of emissions, cities are key actors in our efforts to achieve long-term sustainable solutions to the global climate change challenge, according to Mr. Gurría.

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  • 8-October-2008

    English

    Assessing Climate Change Impacts, Sea Level Rise and Storm Surge Risk in Port Citites: A Case Study on Copenhagen - Environment Working Paper No. 3

    This working paper illustrates a methodology to assess economic impacts of climate change at city scale, focusing on sea level rise and storm surge.

  • 2-October-2008

    English

    OECD Environmental Performance Reviews: Hungary 2008

    OECD's comprehensive review of Hungary's environmental programs and policies, covering air and water management, nature and biodiversity, sustainable development, the environment-economy interface, the environment-social interface, and international commitments. The review includes relevant statistical information as well as a series of recommendations for strengthening environmental infrastructure, implementing environmental policy and integrating environmental concerns into economic decisions.

  • 2-October-2008

    English

    OECD Secretary-General presents review of Hungary’s environment policies

    In the lead-up to joining the European Union, Hungary made significant progress in reducing air and water pollution and protecting its nature and biodiversity says OECD’s latest Review of the Environmental Performance of Hungary.

  • 2-October-2008

    English

    OECD High-level Parliamentary Seminar on Climate Change

    Climate change is confronting us with the fierce urgency of “now”. It concerns the environment as well as the global economy. Global temperatures will continue to rise unless greenhouse gas emissions are reduced significantly. Impacts will include more intense heat waves, droughts, storms and floods, which in turn will cause damage to key infrastructure and crops, and increase risks to human health and life. Action is urgent and

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  • 2-October-2008

    English

    Environmental Performance Reviews: Hungary (2008)

    This book is part of the OECD Environmental Performance Reviews Programme, which conducts peer reviews of environmental conditions and progress in each member country. It scrutinises countries' efforts to meet both domestic objectives and international commitments.

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  • 2-October-2008

    English

    The Conclusions and Recommendations of the OECD Environmental Performance Review

    In the lead-up to joining the European Union, Hungary made significant progress in reducing air and water pollution and protecting its nature and biodiversity, according to Mr. Gurría. However, he recommended that Hungary redouble its efforts, in order to further reduce pollution and use energy and raw materials more efficiently.

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