Latest Documents


  • 26-September-2014

    English

    Test No. 310: Ready Biodegradability - CO2 in sealed vessels (Headspace Test)

    This Test Guideline is a screening method for the evaluation of ready biodegradability of chemicals.

    The test substance, normally at 20 mg C/L, as the sole source of carbon and energy, is incubated (during 28 days normally) in sealed bottles with aerobic condition containing a buffer-mineral salts medium, which has been inoculated with a mixed population of micro-organisms. In order to check the test procedure, a reference

  • 26-September-2014

    English

    Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test

    The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters). Structural chromosome aberrations may be of two types: chromosome or chromatid.

    Animals are exposed to the test substance (liquid or solid) by an appropriate route of exposure (usually by gavage using a

  • 26-September-2014

    English

    Test No. 473: In Vitro Mammalian Chromosomal Aberration Test

    The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian somatic cells. Structural aberrations may be of two types: chromosome or chromatid.

    The in vitro chromosome aberration test may employ cultures of established cell lines, cell strains or primary cell cultures. Cell cultures are exposed to the test substance (liquid or solid) both

  • 26-September-2014

    English

    Test No. 474: Mammalian Erythrocyte Micronucleus Test

    The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).

    The purpose of the micronucleus test is to identify substances (liquid or solid) that cause cytogenetic damage which results in the

  • 26-September-2014

    English, PDF, 293kb

    OECD Guidance on the GLP Requirements for Peer Review of Histopathology

    This advisory document provides guidance on how pathology peer reviews should be planned, conducted and reported within the context of OECD Good Laboratory Practice.

  • 26-September-2014

    English

    OECD Guidance on the GLP Requirements for Peer Review of Histopathology

    This advisory document provides guidance on how pathology peer reviews should be planned, conducted and reported within the context of OECD Good Laboratory Practice.

  • 25-September-2014

    English

    OECD launches its knowledge base on Adverse Outcome Pathways

    The OECD is pleased to announce, together with the U.S Environmental Protection Agency and the European Commission Joint Research Centre, the Adverse Outcome Pathway Knowledge Base (AOP KB). This is a web-based platform which aims to bring together all the knowledge on how chemicals can induce adverse effects, therefore providing a focal point for AOP development and dissemination.

  • 23-September-2014

    English

    OECD participation in the UN Climate Summit

    The UN Climate Summit took place on 23 September 2014 at the United Nations Headquarters in New York. The OECD's Secretary-General, Angel Gurría, chaired the session on "The Economic Case for Climate Action," where global leaders discussed The New Climate Economy Report: Better Growth, Better Climate, by the Global Commission on the Economy and Climate.

  • 23-September-2014

    English

    The climate is changing, so should we - Insights Blog

    The OECD Environment Directorate has produced two videos to explain key climate issues as the UN Climate Summit opens today at UN headquarters in New York.

  • 17-September-2014

    English

    There’s no bailout option for climate - Insights Blog

    Saving the Earth’s climate is sometimes compared to saving the world’s financial system following the crisis in 2007. But it’s not. The taxpayer saved the financial system by bailing it out a cost of trillions of dollars over a very short period, but there is no bailout option for the climate.

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