Latest Documents


  • 13-April-2017

    English

    Report on Considerations from Case Studies on Integrated Approaches for Testing and Assessment (IATA) - First Review Cycle (2015) - Case Studies on Grouping Methods as a Part of IATA

    OECD member countries have been making efforts to expand the use of alternative methods in assessing chemicals. The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of Integrated Approaches for Testing and Assessment (IATA). There is a need for the investigation of the practical applicability of these methods/tools for different aspects of regulatory decision-making, and to build upon case studies and assessment experience across jurisdictions. The objective of the IATA Case Studies Project is to increase experience with the use of IATA by developing case studies, which constitute examples of predictions that are fit for regulatory use. The aim is to create common understanding of using novel methodologies and the generation of considerations/guidance stemming from these case studies. This document reports the learnings and lessons obtained from the review experience of the four case studies submitted to the 2015 review cycle of the IATA Case Studies project. The topics discussed in this document include the strongest aspects and uncertainties of each case study, and the document identifies areas for developing further guidance on IATA.

  • 13-April-2017

    English

    New Scoping Document on in vitro and ex vivo Assays for the Identification of Modulators of Thyroid Hormone Signalling

    This scoping document aims at bringing forward relevant in vitro and ex vivo thyroid assays to the attention of OECD member countries, to provide recommendations for their development/use, and also, to identify aspects/blocks of the thyroid signalling pathways that are not covered and would require further development of thyroid assays.

     

  • 13-April-2017

    English

    Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests

    Acute toxicity tests are an area of focus for developing alternative assays and approaches to address animal welfare concerns. In the context of this document, acute toxicity studies refer to studies involving a single exposure to a test chemical and include those assessing systemic toxicity as well as those assessing local irritation, corrosion or sensitization. One approach to minimizing the use of animals for acute toxicity testing is to consider waiving a study that may be required based on scientific criteria. Another approach to reducing or eliminating animal testing is to use existing hazard information that is informative for the acute toxicity endpoint for the test chemical; this would include the use of hazard information for one or multiple similar test chemicals to characterize the hazard for another or for mixtures, the use of recognized calculation approaches and bridging concepts. This Document provides clarification on these approaches to ensure that regulatory authorities are provided with the appropriate data required for decision-making and that reduced animal testing can be undertaken without compromising the integrity of the hazard information.

     

  • 12-April-2017

    English

    Testing Programme of Manufactured Nanomaterials

    The safety of Manufactured Nanomaterials is an important concern impacting regulatory bodies throughout the world. Due to their size, Manufactured Nanomaterials may require additional testing beyond the standard suite of tests used for other chemicals, to ensure that the impact on human health and the environment is fully understood - download Manufactured Nanomaterials Dossiers or search for Tested Endpoints.

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  • 10-April-2017

    English

    Climate change adaptation and financial protection: Synthesis of key findings from Colombia and Senegal - Environment Working Paper

    Developing countries are disproportionately affected by the rising trend of losses from climate-related extreme events. This paper uses case studies of Colombia and Senegal to examine how countries are using financial protection as part of their approaches to managing climate risks; it also identifies emerging priorities for development co-operation providers in supporting financial protection against climate risks.

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  • 7-April-2017

    English

    OECD environmental data and indicators

    Where to find OECD environmental data? As international concern about global environment and sustainable development becomes more pressing, government, business and the public all need reliable and harmonised data on the environment.

  • 6-April-2017

    English

    Green talks LIVE: Degraded Waters

    On Thursday 6 April, Hannah Leckie & Xavier Leflaive of the OECD Environment Directorate discussed emerging solutions in OECD countries, that can guide the design and implementation of policies to control diffuse water pollution. Water pollution is on the rise due to indirect ‘diffuse’ sources of pollution from both agricultural and urban environments. Watch the video.

  • 31-March-2017

    English

    Household Consumption (EPIC)

    A ground-breaking OECD survey offers insights to policy-makers on the factors that influence household behaviour towards the environment. It provides answers to the key question: How can the impact of policies encouraging greener behaviour be heightened? It also provides a deeper understanding of behavioural responses to measures and how these may differ across households and regions.

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  • 30-March-2017

    English

    Green Growth Indicators

    Green growth is about fostering economic growth and development while ensuring that natural assets continue to provide the resources and environmental services on which our well-being relies. Governments need indicators that can raise awareness, measure progress and identify potential opportunities and risks.

  • 27-March-2017

    English

    Good Laboratory Practice (GLP)

    The OECD Principles of Good Laboratory Practice (GLP) ensure the generation of high quality and reliable test data related to the safety of industrial chemical substances and preparations. The principles have been created in the context of harmonising testing procedures for the Mutual Acceptance of Data (MAD).

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