Testing of chemicals

What's new

 

The Endocrine Disrupters Testing and Assessment (EDTA) Task Force will speed up its validation and reporting activities for test methods in environmental species during 2006-2007.

This includes test methods already on the workplan of the Test Guidelines Programme in the area of fish testing for potential endocrine disrupters, testing on amphibians for the detection of thyroid disruption, and testing on invertebrates for assessment of ED on development and reproduction.

A project, called TESTMETEDECO, is underway to support and strengthen the statistical analysis and reporting of data generated during validation exercises. This follows the objective of the EDTA work to have validated test methods available that can be developed as OECD Test Guidelines that i) have good statistical power, ii) use a minimum number of animals, and iii) are cost-efficient. Their validation is achieved via inter-laboratory exercises using harmonised protocols. The data generated must undergo a statistical analysis to determine their reliability (repeatability and reproducibility). This is done in accordance with OECD Guidance Document 34 on the Validation and International Acceptance of New and Updated Test Methods for Hazard Assessment. The TESTMETEDECO project will support data analysis and production of validation reports. The OECD Secretariat will be engaged in the harmonisation of protocols and in the coordination of validation activities. DG Research at the European Commission is financially supporting this project.

The reports from validation exercises will be made publicly available on the OECD website. Additional news will be posted as the project progresses in 2006-2007.

Publication of Validation Reports

Members of the EDTA Task Force supported the proposal to publish reports of validation exercises as OECD Monographs.  Once reports are approved by the Validation Management Group and the EDTA Task Force, the Joint Meeting will declassify the documents, which will then be published as OECD Monographs and made available to the public.  This initiative will increase transparency of validation activities, which is an important tenet outlined in the draft Guidance Document No. 34 on Validation and Regulatory Acceptance.

 

 

 

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