Testing of chemicals

Section 4: Health Effects

 

important notice

The draft Test Guidelines are not part of Mutual Acceptance of Data (MAD); consult with national authorities before using the draft Test Guidelines.

NEW DEADLINE for comments 

Draft Test Guideline for the Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals
Deadline for public comments*: 25 September 2015

RECENT GUIDELINES

Draft Proposal for a new Test Guideline on in vitro Skin Sensitisation: human Cell Line Activation Test (h-CLAT) 
Deadline for public comments*: 1 July 2015

Draft updated TG 421 on a Reproduction/Developmental Toxicity Screening Test

Draft updated TG 422 on a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test
Approved by WNT (April 2015)

Draft PBTG on human recombinant Estrogen Receptor alpha binding assays
Deadline for public comments*: 5 February 2015

Revised Draft Test Guideline on RhCE Test Method (EpiOcular) for the Detection of Chemicals not Requiring
Classification for Eye Irritation/Serious Eye Damage
Deadline for public comments*: 30 January 2015

Draft Test Guideline on the Short-Time Exposure test method for identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage
Deadline for public comments*: 30 January 2015

Draft Revised Guideline 404 on Acute Dermal Irritation/Corrosion

Draft Revised Guideline 430 on In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)

Draft Revised Guideline 431 on In vitro skin corrosion: reconstructed human epidermis (RHE) test method

Draft Revised Guideline 435 on In Vitro Membrane Barrier Test Method for Skin Corrosion

Draft Revised Guideline 439 on In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method
Deadline for public comments*: 30 January 2015
 

Draft  TG 476  In vitro mammalian cell gene mutation test using the Hprt and xrt genes (PDF)
Deadline for public comments*: 9 January 2015

Draft  TG TK In vitro mammalian cell gene mutation test using the Thymidine kinase gene (PDF)
Deadline for public comments*: 9 January 2015

Draft Proposal for a New Performance Based TG - Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method (PDF)
Draft Performance Standards for New Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method  (PDF)
Multi-study Validation Trial for Cytochrome P450 Induction Providing a Reliable Human Metabolically Competent Standard Model or Method Using the Human Cryopreserved Primary Hepatocytes and the Human Cryopreserved HepaRG® Cell Line (PDF)
Deadline for public comments*: 21 October 2014

Draft Test Guideline on the Cytosensor Microphysiometer Test Method: An in vitro Method for Identifying Ocular 3 Corrosive and Severe Irritant Chemicals as well as Chemicals not Classified as Ocular Irritants (PDF)

Streamlined Summary Document (PDF)
Deadline for public comments*: 11 February 2013

 

further reading

  * Comments should be sent to the Secretariat by National Coordinators by the indicated date. Anyone who would like to contribute to a commenting round is invited to contact their National Coordinator beforehand to discuss together of a timeframe for comment submission.

 

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