Testing of chemicals

Section 4: Health Effects

 

Go to:
- OECD Series on Testing and Assessment (Guidance Documents/Monographs)

 

Adopted Test Guidelines

OECD Test Guidelines are free of charge on OECD iLibrary

 

SOFTWARE FOR TG 455, TG 432 AND TG 425

 

Draft Test Guidelines

WARNING: Draft Test Guidelines are not part of Mutual Acceptance of Data.  Please consult with national authorities before using draft Test Guidelines

 

Instructions for Commenting on Draft Test Guidelines 

Template for submission of comment (optional)

 * Comments should be sent to the Secretariat by National Coordinators by that date. Anyone who would like to contribute to a commenting round is invited to contact their National Coordinator beforehand to discuss together of a timeframe for comment submission.

 

Draft Test Guidelines

 
Draft updated TG 421 on a Reproduction/Developmental Toxicity Screening Test
Draft updated TG 422 on a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test

Deadline for public comments*: 5 February 2015

Draft PBTG on human recombinant Estrogen Receptor alpha binding assays
Deadline for public comments*: 5 February 2015

Revised Draft Test Guideline on RhCE Test Method (EpiOcular) for the Detection of Chemicals not Requiring
Classification for Eye Irritation/Serious Eye Damage

Deadline for public comments*: 30 January 2015

Draft Test Guideline on the Short-Time Exposure test method for identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

Deadline for public comments*: 30 January 2015

Draft Revised Guideline 404 on Acute Dermal Irritation/Corrosion

Draft Revised Guideline 430 on In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)

Draft Revised Guideline 431 on In vitro skin corrosion: reconstructed human epidermis (RHE) test method

Draft Revised Guideline 435 on In Vitro Membrane Barrier Test Method for Skin Corrosion

Draft Revised Guideline 439 on In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method

Deadline for public comments*: 30 January 2015
 

Draft  TG 476  In vitro mammalian cell gene mutation test using the Hprt and xrt genes (PDF)
Deadline for public comments*: 9 January 2015

Draft  TG TK In vitro mammalian cell gene mutation test using the Thymidine kinase gene (PDF)
Deadline for public comments*: 9 January 2015

Draft Proposal for a New Performance Based TG - Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method (PDF)
Draft Performance Standards for New Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method  (PDF)
Multi-study Validation Trial for Cytochrome P450 Induction Providing a Reliable Human Metabolically Competent Standard Model or Method Using the Human Cryopreserved Primary Hepatocytes and the Human Cryopreserved HepaRG® Cell Line  (PDF)

Deadline for public comments*: 21 October 2014

 

Draft Proposal for a new Test Guideline on in vitro Skin Sensitisation: human Cell Line Activation Test (h-CLAT) (PDF)
Deadline for public comments*: 13 October 2014

Draft revised TG 478- Rodent Dominant Lethal Test (PDF)
Draft revised TG 483 - Mammalian Spermatogonial Chromosomal Aberration Test (PDF)
Deadline for public comments*: 10 October 2014

Draft new Test Guideline on Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage (PDF)
Deadline for public comments*: 6 October 2014

Draft revised Guideline 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER) (PDF)
Deadline for public comments*: 15 September 2014

Draft revised Guideline 431:In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method (PDF)
Deadline for public comments*: 15 September 2014

Draft revised Guideline 404: Acute Dermal Irritation/Corrosion (PDF)
Deadline for public comments*: 15 September 2014

Draft revised Guideline 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method (PDF)
Deadline for public comments*: 15 September 2014

Draft revised Guideline 435: In Vitro Membrane Barrier Test Method for Skin Corrosion (PDF)
Deadline for public comments*: 15 September 2014

Guideline for the Testing of Chemicals: New Test Guideline - In Vitro Mammalian Cell Gene Mutation Assays Using the Thymidine Kinase Gene (PDF)
Deadline for public comments*: 12 September 2014

Proposal for updating Guideline 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt Genes (PDF)
Deadline for public comments*: 12 September 2014

Draft Updated TG 455: Draft Performance-Based Test Guideline for Stably Transfected Transactivation in vitro Assays to Detect Estrogen Receptor Agonists and Antagonists (PDF)
Deadline for public comments*: 1 September 2014

Draft TG on the Short Time Exposure in vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritatin or Serious Eye Damage (PDF)
Deadline for public comments*: 1 September 2014


In chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA)
In vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method
Deadline for public comments*: 30 June 2014

 

In Vitro Carcinogenicity: Bhas 42 Cell Transformation Assay (PDF)

Deadline for public comments*: 9 December 2013


In vitro Carcinogenicity: Syrian Hamster Embryo (SHE) Cell Transformation Assay (PDF)
Date of the draft : February 2013


Draft Test Guideline on the Cytosensor Microphysiometer Test Method: An in vitro Method for Identifying Ocular 3 Corrosive and Severe Irritant Chemicals as well as Chemicals not Classified as Ocular Irritants (PDF)

Streamlined Summary Document (PDF)
Deadline for public comments*: 11 February 2013

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