Testing of chemicals

Section 4: Health Effects

 

important notice

The draft Test Guidelines are not part of Mutual Acceptance of Data (MAD); consult with national authorities before using the draft Test Guidelines.

NEW DEADLINE for comments 

Guidance Document on Revisions to OECD Genetic Toxicology Test Guidelines
Deadline for public comments*: 16 October 2015

Draft Test Guideline for the Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals
Deadline for public comments*: 25 September 2015

RECENT GUIDELINES

Draft Proposal for a new Test Guideline on in vitro Skin Sensitisation: human Cell Line Activation Test (h-CLAT) 
Deadline for public comments*: 1 July 2015

Draft updated TG 421 on a Reproduction/Developmental Toxicity Screening Test

Draft updated TG 422 on a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test
Approved by WNT (April 2015)

Draft PBTG on human recombinant Estrogen Receptor alpha binding assays
Deadline for public comments*: 5 February 2015

Revised Draft Test Guideline on RhCE Test Method (EpiOcular) for the Detection of Chemicals not Requiring
Classification for Eye Irritation/Serious Eye Damage
Deadline for public comments*: 30 January 2015

Draft Test Guideline on the Short-Time Exposure test method for identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage
Deadline for public comments*: 30 January 2015

Draft Revised Guideline 404 on Acute Dermal Irritation/Corrosion

Draft Revised Guideline 430 on In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)

Draft Revised Guideline 431 on In vitro skin corrosion: reconstructed human epidermis (RHE) test method

Draft Revised Guideline 435 on In Vitro Membrane Barrier Test Method for Skin Corrosion

Draft Revised Guideline 439 on In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method
Deadline for public comments*: 30 January 2015
 

Draft  TG 476  In vitro mammalian cell gene mutation test using the Hprt and xrt genes (PDF)
Deadline for public comments*: 9 January 2015

Draft  TG TK In vitro mammalian cell gene mutation test using the Thymidine kinase gene (PDF)
Deadline for public comments*: 9 January 2015

Draft Proposal for a New Performance Based TG - Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method (PDF)
Draft Performance Standards for New Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method  (PDF)
Multi-study Validation Trial for Cytochrome P450 Induction Providing a Reliable Human Metabolically Competent Standard Model or Method Using the Human Cryopreserved Primary Hepatocytes and the Human Cryopreserved HepaRG® Cell Line (PDF)
Deadline for public comments*: 21 October 2014

Draft Test Guideline on the Cytosensor Microphysiometer Test Method: An in vitro Method for Identifying Ocular 3 Corrosive and Severe Irritant Chemicals as well as Chemicals not Classified as Ocular Irritants (PDF)

Streamlined Summary Document (PDF)
Deadline for public comments*: 11 February 2013

 

further reading

  * Comments should be sent to the Secretariat by National Coordinators by the indicated date. Anyone who would like to contribute to a commenting round is invited to contact their National Coordinator beforehand to discuss together of a timeframe for comment submission.

 

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