Testing of chemicals

Section 4: Health Effects

 

important notice

The draft Test Guidelines are not part of Mutual Acceptance of Data (MAD); consult with national authorities before using the draft Test Guidelines.

NEW DEADLINE for comments 

Deadline for comments: 6 October 2017

Draft TG 442D on in vitro skin sensistisation: ARE-Nrf2 Luciferase Test Method

Deadline for comments: 6 October 2017

Draft Skin Sensitisation TG 442B: Local Lymph Node Assay: BrdU-ELISA or –FCM

Deadline for comments: 29 September 2017

Draft updated TG 492 on Reconstructed human Corneal Epithelium for Eye hazard potential, including the LabCyte model

Deadline for comments 18 August 2017

Draft revised TG 408 - Repeated Dose 90-day Oral Toxicity Study

Deadline for comments 10 February 2017

Draft revised TG 412 - Subacute Inhalation Toxicity to Accommodate Nanomaterials

Draft revised TG 413 - Subchronic Inhalation Toxicity to Accommodate Nanomaterials

Deadline for public comments: 7 February 2017

Draft TG on In Vitro Skin Sensitisation: U937 Skin Sensitisation Test (U-SENS™)

Draft TG on In Vitro Skin Sensitisation: IL-8 Luc assay

Draft Guideline: ROS (Reactive Oxygen Species) assay for photosafety

 

RECENT DRAFT GUIDELINES

Draft revised TG 438 on Isolated Chicken eye test document

Deadline for public comments*: 30 October 2015

Supporting document for amending Decision Criteria in TG 438
Deadline for public comments*: 30 October 2015

Draft Proposal for a New Performance Based TG - Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method (PDF)

Draft Performance Standards for New Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method  (PDF)
Multi-study Validation Trial for Cytochrome P450 Induction Providing a Reliable Human Metabolically Competent Standard Model or Method Using the Human Cryopreserved Primary Hepatocytes and the Human Cryopreserved HepaRG® Cell Line (PDF)
Deadline for public comments*: 21 October 2014

 

further reading

* Comments should be sent to the Secretariat by National Coordinators by the indicated date. Anyone who would like to contribute to a commenting round is invited to contact their National Coordinator beforehand to discuss together of a timeframe for comment submission.

 

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