Testing of chemicals

Reproductive Toxicity


TG 414: Prenatal development toxicity study (2001)
TG 415: One-generation reproduction toxicity study (1983)
TG 416: Two-generation reproduction toxicity (2001)
TG 421: Reproduction/developmental toxicity screening test (1995)
TG 422: Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (1996)

TG 443: Extended one-generation reproductive toxicity study (2011)
•    No 117: Guidance document on the current implementation of internal triggers in test guideline 443 for an extended
                     one generation reproductive toxicity study, in the United States and Canada
•    No 151: Guidance document supporting OECD test guideline 443 on the extended one-generation reproductive toxicity test

No 176:
Report on the retrospective analysis of 2-generation reprotoxicity data

General documents:

No 43: Guidance document on mammalian reproductive toxicity testing and assessment
No 106: Guidance document for histologic evaluation of endocrine and reproductive tests in rodents