Testing of chemicals

Lists of projects on the AOP development programme workplan

 

 

 

SECTION 1: Development of an adverse outcome pathway

Project 1.1: The Adverse Outcome Pathways for Skin Sensitisation Initiated by Covalent Binding to Proteins.

Lead:

Inclusion in work plan:

Secretariat + consultant

2011

Project 1.2: The Adverse Outcome Pathways for Nonpolar Narcosis.

Lead:

Inclusion in work plan:

United States

2012

 

Project 1.3: The Adverse Outcome Pathways for Acetylcholinesterase Inhibition.

Lead:

Inclusion in work plan:

United States

2012

 

Draft AOP ready September 2013.

Project 1.4: Adverse Outcome Pathways for Five Cell Signalling Pathways Associated with Cell Proliferation and Differentiation that are Conserved Across Species.

Lead:

Inclusion in work plan:

Secretariat + consultant

2010

 

Project 1.5: Two Adverse Outcome Pathways for Mitochondrial Toxicity.

Lead:

Inclusion in work plan:

Secretariat + consultant

2011

 

Project 1.6: The Adverse Outcome Pathways for Embryonic Vascular Disruption and Developmental Defects.

Lead:

Inclusion in work plan:

United States

2013

 

In progress, important milestones in 2013-2014.

Project 1.7: The Adverse Outcome Pathways for Sustained Activation of the Avian Aryl Hydrocarbon Receptor.

Lead:

Inclusion in work plan:

Canada, BIAC

2013

 

Project 1.8: The Adverse Outcome Pathways for Mutagenic Modes of Action for Cancer.

Lead:

Inclusion in work plan:

United States

Pending further review by EAGMST

 

Project 1.9: The Adverse Outcome Pathway on Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals.

Lead:

Inclusion in work plan:

United States

2013

 

Draft AOP ready October 2013.

Project 1.10: The Adverse Outcome Pathway on Xenobiotic Induced Inhibition of Thyroperoxidase and Depressed Thyroid Hormone Synthesis and Subsequent Adverse Neurodevelopmental Outcomes in Mammals.

Lead:

Inclusion in work plan:

United States

2013

 

Draft AOP ready October 2013.

Project 1.11: The Adverse Outcome Pathways for Heritable Germ Cell-Derived Disease (3 AOPs).

Lead:

Inclusion in work plan:

Canada

2013

 

AOP 1: Alkylation of DNA in male pre-meiotic germ cells causing inherited mutation; draft AOP ready in July 2013.

AOP 2: Chemical interaction with tubulin in oocytes leading to inherited aneuploidy; draft AOP ready in September 2013.

AOP 3: Stable bulky DNA adducts in male pre-meiotic germ cells causing point mutation leading to inherited DNA sequence mutation; draft AOP ready in January 2014.

Project 1.12: The Adverse Outcome Pathways linking Aromatase Inhibition, Androgen Receptor Agonism, Estrogen Receptor Antagonism, or Steroidogenesis Inhibition, to Impaired Reproduction in Small Repeat-Spawning Fish Species.

Lead:

Inclusion in work plan:

United States

2013

 

Draft AOP submitted to OECD in April 2013.

Project 1.13: The Adverse Outcome Pathway on Neurotoxicant-induced Neuroinflammation: a converging key event in an adverse outcome pathway.

Lead:

Inclusion in work plan:

Switzerland

Pending review by EAGMST

 

Project 1.14: The Adverse Outcome Pathways from protein alkylation to liver fibrosis.

Lead:

Inclusion in work plan:

 

European Commission

2013

 

In progress, identification of partners.

Project 1.15: The Adverse Outcome Pathways for Neurotoxicity induced by GABAA receptor inhibition.

Lead:

Inclusion in work plan:

United States

2013

 

Draft AOP ready in September 2013.

Project 1.16: The Adverse Outcome Pathway Describing Hematotoxicity due to Nitroaromatics and N-hydroxyl anilines.

Lead:

Inclusion in work plan:

United States

2013

 

Draft AOP ready in September 2013.

Project 1.17: The Adverse Outcome Pathway on CAR and PPARα-mediated pathways to non-genotoxic rodent liver cancer.

Lead:

Inclusion in work plan:

United States

2013

 

Draft AOP ready in February-April 2014.

Project 1.18: The Adverse Outcome Pathway on CAR and PXR-mediated pathways to rodent liver hyperplasia.

Lead:

Inclusion in work plan:

United States

2013

 

Draft AOP ready in March 2014.

 

SECTION 2: Development of an adverse outcome pathway case study

Project 2.1: The Adverse Outcome Pathways- Case Studies Using Aquatic Organism.

Lead:

Inclusion in work plan:

United Kingdom and Japan

2013

 

Project 2.2: The Adverse Outcome Pathway on Hepatotoxicity due to 2,4,6-trinitrotoluene.

Lead:

Inclusion in work plan:

United States

2013

 

Draft AOP ready in September 2013.

Project 2.3: The Adverse Outcome Pathway on Energy Metabolism by 2,6-Dinitroluene.

Lead:

Inclusion in work plan:

United States

2013

 

Draft AOP ready in September 2013.

SECTION 3: Guidance documents related to adverse outcome pathway development including its evaluation

Project 3.1: Development of a Template for Recording Adverse Outcome Pathways (AOPs) and Associated Guidance Relating to How to Assess its Completeness.

Lead:

Inclusion in work plan:

 

Secretariat

2011

 

Completed: Guidance and template published (No. 184 in OECD Series on Testing and Assessment)

Project 3.2: Glossary of the Terminology Associated with Adverse Outcome Pathways.

Lead:

Inclusion in work plan:

Secretariat

2011

 

SECTION 4:  Knowledge management tool

Project 4.1: Web Based AOP Knowledge Management Tool.

Lead:

Inclusion in work plan:

United States

2013

In development and beta-testing in 2013.

Project 4.2: Adverse Outcome Pathways Knowledge Base (AOP-KB).

Lead:

Inclusion in work plan:

European Commission and United States

2013

 

In progress.

SECTION 5: Others

Project 5.1: In vitro test method development strategy for the OECD Skin Sensitisation AOP.

Lead:

Inclusion in work plan:

EC/ECVAM

2013

 

 

 

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