Testing of chemicals

Level 4: In vivo Assays Providing Data of Adverse Effects on Endocrine Relevant Endpoints

 


Only endocrine disruptors related documents are included here. Please refer to the description by types of hazard for any other documents associated to the Test Guidelines mentioned below.

Repeated Dose 28-day Study

TG 407: Repeated Dose 28-day Oral Toxicity Study in Rodents
•    No 59: Report of the Validation of the Updated Test Guideline 407 - Repeat Dose 28-day Oral Toxicity Study in Laboratory Rats
•    No 81: Summary Report of the Validation Peer Review for the Updated Test Guideline 407, and Agreement of the Working
                  Group of the National Coordinators of the Test Guidelines Programme on the Follow-up of this Report


General Documents

•    No 106: Guidance Document for Histologic Evaluation of Endocrine and Reproductive Tests in Rodents  Part 1, Part 2
      => This document provides guidance for histopathological examinations and is also applicable to other test guidelines.


Other Test Guidelines

TG 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents
TG 415: One-Generation Reproduction Toxicity Study
TG 414: Prenatal Development Toxicity Study
TG 451: Carcinogenicity Studies
TG 453: Combined Chronic Toxicity/Carcinogenicity Studies
TG 421: Reproduction/Developmental Toxicity Screening Test
TG 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test
TG 426: Developmental Neurotoxicity Study

 

 

 

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