Testing of chemicals

Level 3: In vivo Assays Providing Data on Selected Endocrine Mechanism(s)/Pathway(s)

 

Uterotrophic Assay

TG 440: Uterotrophic bioassay in rodents (2007)
•    No 38: Detailed background review of the uterotrophic bioassay
•    No 65: OECD report of the initial work towards the validation of the rodent uterothophic assay - phase 1
•    No 66: OECD report of the validation of the rodent uterotrophic bioassay - phase 2: testing of potent and weak
                  oestrogen agonists by multiple laboratories
•    No 67: Report of the uterotrophic bioassay: additional data supporting the test guideline on the uterotrophic
                  bioassay in rodents
•    No 68: Summary report of the uterothropic bioassay peer review panel, including assessment of the Working Group of
                   the National Coordinators of the Test Guidelines Programme on the follow-up of this report
•    No 71: Guidance document on the uterothrophic bioassay - procedure to test for antioestrogenicity


Hershberger Assay

TG 441: Hershberger bioassay in rats (2009)
•    No 62: Final OECD report of the initial work towards the validation of the rat hershberger assay
                  - phase 1: androgenic response to testosterone propionate, and anti-androgenic effects of flutamide
•    No 73: Report of the validation of the rat hershberger assay - phase 3: coded testing of androgen agonists,
                  androgen antagonists and negative reference chemicals by multiple laborotories. Surgical castrate model protocol.
•    No 85: Report of the validation peer review for the hershberger bioassay, and the agreement of the Working Group
                  of the National Coordinators of the Test Guidelines Programme on the follow-up of this report
•    No 86: Report of the OECD validation of the rodent hershberger bioassay - phase 2: testing of androgen agonists,
                   androgen antagonists and a 5 α-reductase inhibitor in dose response studies by multiple laboratories
•    No 90: Background review document on the rodent hershberger bioassay
•    No 108: Report of the validation of the hershberger bioassay (Weanling Model)
•    No 110: Report of the validation peer review for the weanling hershberger bioassay and agreement of the Working
                    of National Coordinators of the Test Guidelines Programme on the follow-up of this report
•    No 115: Guidance document on the weanling hershberger bioassay in rats: A short-term screening assay for
                     (Anti) androgenic properties

 

 

 

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