Testing of chemicals

Level 3: In vivo Assays Providing Data on Selected Endocrine Mechanism(s)/Pathway(s)

 

Uterotrophic Assay

TG 440: Uterotrophic Bioassay in Rodents
•    No 38: Detailed Background Review of the Uterotrophic Bioassay
•    No 65: OECD Report of the Initial Work Towards the Validation of the Rodent Uterothophic Assay - Phase 1
•    No 66: OECD Report of the Validation of the Rodent Uterotrophic Bioassay - Phase 2: Testing of Potent and Weak
                  Oestrogen Agonists by Multiple Laboratories
•    No 67: Report of the Uterotrophic Bioassay: Additional Data Supporting the Test Guideline on the Uterotrophic
                  Bioassay in Rodents
•    No 68: Summary Report of the Uterothropic Bioassay Peer Review Panel, including Assessment of the Working Group of
                   the National Coordinators of the Test Guidelines Programme on the Follow-up of this Report
•    No 71: Guidance Document on the Uterothrophic Bioassay - Procedure to Test for Antioestrogenicity


Hershberger Assay

TG 441: Hershberger Bioassay in Rats
•    No 62: Final OECD Report of the Initial Work Towards the Validation of the Rat Hershberger Assay
                  - Phase 1: Androgenic Response to Testosterone Propionate, and Anti-Androgenic Effects of Flutamide
•    No 73: Report of the Validation of the Rat Hershberger Assay - Phase 3: Coded Testing of Androgen Agonists,
                  Androgen Antagonists and Negative Reference Chemicals by Multiple Laborotories. Surgical Castrate Model Protocol.
•    No 85: Report of the Validation Peer Review for the Hershberger Bioassay, and the Agreement of the Working Group
                  of the National Coordinators of the Test Guidelines Programme on the Follow-up of this Report
•    No 86: Report of the OECD Validation of the Rodent Hershberger Bioassay - Phase 2: Testing of Androgen Agonists,
                   Androgen Antagonists and a 5 α-Reductase Inhibitor in Dose Response Studies by Multiple Laboratories
•    No 90: Background Review Document on the Rodent Hershberger Bioassay
•    No 108: Report of the Validation of the Hershberger Bioassay (Weanling Model)
•    No 110: Report of the Validation Peer Review for the Weanling Hershberger Bioassay and Agreement of the Working
                    of National Coordinators of the Test Guidelines Programme on the Follow-up of this Report
•    No 115: Guidance Document on the Weanling Hershberger Bioassay in Rats: A Short-term Screening Assay for
                     (Anti) Androgenic Properties

 

 

 

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