Testing of chemicals

Level 2: In vitro Assays Providing Data on Selected Endocrine Mechanism(s)/Pathway(s)

 

Estrogen Receptor Transactivation

TG 455: Performance-based test guideline for stably transfected transactivation in vitro assays to detect estrogen receptor agonists (2012)
•    No 83: Summary report of the peer review panel on the stably transfected transcriptional activation assay for
                   detecting estrogenic activity of chemicals, and agreement of the Working Group of National Coordinators
                   of Test Guidelines Programme on the follow-up of this report
•    No 173: Performance standards for stably transfected transactivation in vitro assays to detect estrogen agonists for TG 455

 

TG 457: BG1Luc estrogen receptor transactivation test method for identifying estrogen receptor agonists and antagonists (2012)
•    No 174: Performance standards for the BG1Luc ER TA transactivation method to detect estrogen receptor antagonists

 

Steroidogenesis in vitro

TG 456: H295R steroidogenesis assay (2011)
•    No 132: Report of the multi-laboratory validation of the H295R steroidogenesis assay to identify modulators
•    No 133: Peer review report for the H295R cell-based assay for steroidogenesis

 


Desruptors of Thyroid Hormone Signalling Pathways

•    No 207: Scoping document on in vitro and ex vivo assays for the identification of modulators of thyroid hormone signalling

 

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